Note that this sequence is derived from at least two T. brucei strains. Several polymorphisms exist between these strains.
LOCUS TRBKPGEN 23016 bp ds-DNA ORG 26-JUN-1992
DEFINITION Trypanosoma brucei brucei kinetoplast maxicircle genes, putative
cds.
ACCESSION M94286
KEYWORDS 12S ribosomal RNA; 9S ribosomal RNA; NADH dehydrogenase subunit 1;
NADH dehydrogenase subunit 4; NADH dehydrogenase subunit 5;
NADH dehydrogenase subunit 7; apocytochrome B;
cytochrome oxidase subunit 1; cytochrome oxidase subunit 2;
cytochrome oxidase subunit 3; kinetoplast maxicircle;
mitochondrial DNA; replication origin; ribosomal protein S12.
SOURCE Kinetoplast Trypanosoma brucei brucei (strain EATRO 427, chromosome
Kinetoplast Trypanosoma brucei brucei, sub_species brucei)
procyclic DNA.
ORGANISM Kinetoplast Trypanosoma brucei brucei
Eukaryota; Animalia; Protozoa; Sarcomastigophora; Mastigophora;
Kinetoplastida; Trypanosomatina; Trypanosomatidae.
REFERENCE 1 (sites)
AUTHORS Eperon,I.C., Janssen,J.W., Hoeijmakers,J.H. and Borst,P.
TITLE The major transcripts of the kinetoplast DNA of Trypamosoma brucei
are very small ribosomal RNAs
JOURNAL Nucleic Acids Res. 11, 105-125 (1983)
STANDARD full staff_review
REFERENCE 2 (sites)
AUTHORS Benne,R., De Vries,B.F., Van Den Burg,J. and Klaver,B.
TITLE The nucleotide sequence of a segment of Trypanosoma brucei
mitochondrial maxi-circle DNA that contains the gene for
apocytochrome b and some unusual unassigned reading frames
JOURNAL Nucleic Acids Res. 11, 6925-6941 (1983)
STANDARD full staff_review
REFERENCE 3 (sites)
AUTHORS Hensgens,L.A., Brakenhoff,J.P., De Vries,B.F., Sloof,P.,
Tromp,M.C., van Boom,J.H. and Benne,R.
TITLE The sequence of the gene for cytochrome c oxidase subunit I, a
frameshift containing gene for cytochrome c oxidase subunit II and
seven unassigned reading frames in Trypanosoma brucei mitochondrial
maxi-circle DNA
JOURNAL Nucleic Acids Res. 12, 7327-7344 (1984)
STANDARD full staff_review
REFERENCE 4 (sites)
AUTHORS Stuart,K.D., Jasmer,D.P. and Feagin,J.E.
TITLE Apocytochrome b and other mitochondrial DNA sequences are
differentially expressed during the life cycle of Trypanosoma
brucei
JOURNAL Nucleic Acids Res. 13, 4577-4596 (1985)
STANDARD full staff_review
REFERENCE 5 (sites)
AUTHORS Benne,R., Van den Burg,J., Brakenhoff,J.P., Sloof,P., van Boom,J.H.
and Tromp,M.C.
TITLE Major transcript of the frame shifted coxII gene from Trypanosome
mitochondria contains four nucleotides that are not encoded in the
DNA
JOURNAL Cell 46, 819-826 (1986)
STANDARD full staff_review
REFERENCE 6 (sites)
AUTHORS Feagin,J.E., Abraham,J.M. and Stuart,K.D.
TITLE Developmental regulated addition of nucleotides within
apocytochrome b transcripts in Trypanosoma brucei
JOURNAL Cell 49, 337-345 (1987)
STANDARD full staff_review
REFERENCE 7 (sites)
AUTHORS Shaw,J.M., Feagin,J.E., Stuart,K.D. and Simpson,L.
TITLE Editing of kinetoplastid mitochondrial mRNAs by uridine addition
and deletion generates conserved amino acid sequences and AUG
initiation codons
JOURNAL Cell 53, 401-411 (1988)
STANDARD full staff_review
REFERENCE 8 (sites)
AUTHORS Stuart,K.D., Abraham,J.M. and Feagin,J.E.
TITLE Extensive editing of the cytochrome c oxidase III transcript in
Trypanosoma brucei
JOURNAL Cell 53, 413-422 (1988)
STANDARD full staff_review
REFERENCE 9 (sites)
AUTHORS de Vries,B.F., Mulder,E., Brakenhoff,J.P., Sloof,P. and Benne,R.
TITLE The variable region of the Trypanosoma brucei kinetoplast
maxicircle: sequence and transcript analysis of a repetitive and a
non-repetitive fragment
JOURNAL Mol. Biochem. Parasitol. 27, 71-82 (1988)
STANDARD full staff_review
REFERENCE 10 (sites)
AUTHORS Bhat,G.J., Koslowsky,D.J., Feagin,J.E., Smiley,B.L. and Stuart,K.D.
TITLE An extensively edited mitochondrial transcript in kinetoplastids
encodes a protein homologous to ATPase subunit 6
JOURNAL Cell 61, 885-894 (1990)
STANDARD full staff_review
REFERENCE 11 (sites)
AUTHORS Koslowsky,D.J., Bhat,G.J., Perrollaz,A.L., Feagin,J.E. and
Stuart,K.D.
TITLE The MURF3 gene of Trypanosoma brucei contains multiple domains of
extensive editing and is homologous to a subunit of NADH
dehydrogenase
JOURNAL Cell 62, 901-911 (1990)
STANDARD full staff_review
REFERENCE 12 (bases 1 to 23016)
AUTHORS Sloof,P., De Haan,A., Eier,W., Van Iersel,M., Boel,E., Van Steeg,H.
and Benne,R.
TITLE The nucleotide sequence of the variable region of trypanosoma
brucei completes the sequence analysis of the maxicircle component
of mitochondrial kinetoplast DNA
JOURNAL Unpublished (1992)
STANDARD full automatic
REFERENCE 13 (sites)
AUTHORS Simpson,L., Peris,M., Gruszynski,E.S., Niner,B.M., Sturm,N.R. and
Maslov,D.A.
TITLE An intergenic G-rich region in Leishmania tarentolae kinetoplast
maxicircle DNA is a pan-edited cryptogene encoding ribosomal
protein S12
JOURNAL Mol. Cell. Biol. 12, 56-67 (1992)
STANDARD full staff_review
REFERENCE 14 (sites)
AUTHORS Souza,A.E., Myler,P.J. and Stuart,K.D.
TITLE Maxicirle CR1 transcripts of Trypanosoma brucei are edited and
developmentlly regulated and encode a putative iron-sulfur protein
homologous to an NADH dehydrogenase subunit
JOURNAL Mol. Cell. Biol. 12, 2100-2107 (1992)
STANDARD full staff_review
COMMENT The lack of translational initiation- and stop codons, the
presence of reading frame shifts and in some cases a nonsense
nucleotide sequence in Trypanosomal maxicirle gene is an
inhetent feature of these genes. These gene-encoded defects
are removed at the transcript level by a process which we
have discovered in 1986 and have baptized RNA-editing (see
Benne et al (1986), Cell 46, 819-826; Benne (1990), Trends
Genet. 6, 177-181).
The appropriate amino acid sequences cannot be translated
from the gene nucleotide sequences, but exclusively from
fully edited transcript sequences. The references in which
transcript sequences have been determined are listed as
citations in the appropriate features.
The ND8 transcript is edited over its entire length and
only the aa sequence deduced from the fully edited transcript
reveals similarity with ND8, as has been described by Souza,
Myler and Stuart (1992) Mol.Cell.Biol. 12, 2100-210
FEATURES Location/Qualifiers
misc_feature 1364..2512
/note="pre-RNA-edited gene nucleotide sequences"
/product="12S ribosomal RNA"
/gene="12S rRNA"
misc_feature 2542..3152
/note="pre-RNA-edited gene nucleotide sequences"
/product="9S ribosomal RNA"
/gene="9S rRNA"
misc_feature 4066..4767
/note="pre-RNA-edited gene nucleotide sequences"
/product="NADH dehydrogenase subunit 7"
/gene="ND7"
/citation=[11]
misc_feature 4768..5206
/note="pre-RNA-edited gene nucleotide sequences"
/product="cytochrome oxidase subunit 3"
/gene="COIII"
/citation=[8]
misc_feature 5275..6354
/note="pre-RNA-edited gene nucleotide sequences"
/product="apocytochrome b"
/gene="Cyb"
/citation=[6]
misc_feature complement(6397..6765)
/note="pre-RNA-edited gene nucleotide sequences"
/note="putative maxicircular unidentified reading frame 4"
/product="ATPase subunit 6 homologue"
/gene="MURF4"
/citation=[10]
misc_feature complement(6839..8075)
/note="pre-RNA-edited gene nucleotide sequences"
/note="putative maxicircular unidentified reading frame 1"
/gene="MURF1"
misc_feature complement(8166..9122)
/note="pre-RNA-edited gene nucleotide sequences"
/product="NADH dehydrogenase subunit 1"
/gene="ND1"
misc_feature 9111..9736
/note="pre-RNA-edited gene nucleotide sequences"
/product="cytochrome oxidase subunit 2"
/gene="COII"
/citation=[5]
misc_feature complement(9775..10815)
/note="pre-RNA-edited gene nucleotide sequences"
/note="putative maxicircular unidentified reading frame 2"
/gene="MURF2"
/citation=[7]
misc_feature complement(10712..12445)
/note="pre-RNA-edited gene nucleotide sequences"
/product="cytochrome oxidase subunit 1"
/gene="COI"
misc_feature 12780..14090
/note="pre-RNA-edited gene nucleotide sequences"
/product="NADH dehydrogenase subunit 4"
/gene="ND4"
misc_feature 14310..14481
/note="pre-RNA-edited gene nucleotide sequences"
/product="ribosomal protein S12"
/gene="RPS12"
/citation=[13]
misc_feature 14490..16259
/note="pre-RNA-edited gene nucleotide sequences"
/product="NADH dehydrogenase subunit 5"
/gene="ND5"
rep_origin complement(19854..19865)
rep_origin complement(20670..20681)
BASE COUNT 9706 a 2121 c 3242 g 7947 t
ORIGIN
1 gaattcctca agtccctaat tgcgattatt tgttaagatc tttttgagga tagatctaaa
61 attaccaagt ccaatttttg tatatgggcg ggctatgaaa atataaaatt atatattttc
121 tagtttgatc gaaaatgctt ttcgatttga aaatttaaat taaatttaag tttaattttc
181 aattttcaaa atttgaaaca attttggaat tttggtaggt attttattga taggtttaaa
241 tcaccgctgt ataaattttg gtagtaaaac tttttgtaat aatgcgtttt tattatcagt
301 tatttatggg tgtttgtgat ttaaatgtaa tcagtttagt acaaatcatt tttctaaatt
361 attttgagtt ttgggatttg gaggtttgaa cttgaattta aatttagttt caagtcaagt
421 cgtataaaaa acatggcatt ttttgttgct ataagttttt tatataactc tttgattcga
481 aattaaattt aaatttaggt tttagctatt ttaaattcca acttgaaatt tgttttgggt
541 ttttataatt gagttttaaa ttttaaatcc aaatttaaat aggatcttct ttactaatga
601 aaatatttta caaatctttt gcaaaaatat tttaatttag taaggatggt tggtatttta
661 aatttcggtt taatttttaa aattttttta ttgaccaaac attttcaagg ttagtgggaa
721 tagctatgac tttggtttag atttagtttt atcattgaat tgttatgtaa aggatttgtg
781 gttatacaat atgtttatgt atgtgtttat tatatgtact cgattagaga agctaaactt
841 aaattcaaac ctccaatttc caaaacttga aacaattttt aggtgattta ttaagaattg
901 atttaaaatt atgaatgtat aaattttggt agtaggtttt ttttgtaata atgtgtttat
961 aaattgtaac taatctggtt taaactattt ttctaaatta ttttaggttt tttttgggac
1021 atgagagttt aaatttgaat ttacttttaa gttatcaata aaaaacatgt tttttgtgct
1081 attaaaattt atataatctt tttgacgtca aatttaaatt taggtttatt ctaattcgaa
1141 actttttggt tttttaataa ataactccaa taaatctaaa tttttttata gatcaaacat
1201 ttttaaggtt ggtaggcata gttatgactt tctagtttaa tttagtttta tttattgaat
1261 tgttatgtaa aggatttgtg gttgggaatg tttatgttta tgtttattat gtgtatttta
1321 tttaattaga aaagctttta aaaatttaaa atttgtaatc caaattttac caattaagaa
1381 gaatattata ataatgggtg tcttatattt taaataaata tttaaattcc gtgtagtaaa
1441 tttattattt gtattattta tataataggt gtattatatt taaattttaa atttgttgtt
1501 ttatatttag atacatattt atagattaat atatttaaat aatattttaa aatttattga
1561 actgtaatta ttagtttaat atttttagtt tgatgttgaa atatttaatt aaagatgtta
1621 cagttgttct atatgtacca aataaatata gtaagattat tttagttgaa ttaataaata
1681 aatatttatt tttctttgta aatattatga acaatttaaa aattaatctg tttaactaaa
1741 atgttatata taataatcta agttaatttg aatattaaaa gtacaagtat aatttgtaat
1801 tctaaagtat tttaatggta tatttttagt aggtaaatga aaagtataaa tggatataac
1861 ttaatattta atatttgttt aatgaaaagt attttattat tatattgtat agtattatta
1921 tagtgtatag ttttttaaaa atataaaaat attgttaata aaattatcgt attttaagtg
1981 cgtttattaa atgcgtttgt ctaagataat tatttaagat tattcttgta aatatattta
2041 aatattaata attcttaaaa taaaaaaata tcctcaattg caatattatt gtagcatagt
2101 aatttgttaa ctaaatatta aagtgttcca tagaaaattt ttaaattaca acaaataaaa
2161 taaagtatga attaatatca aaattttaat aaaaattaaa aaattaaaat agggcaagtc
2221 ctactctcct ttacaaagag aacattatga tatgtaattg tatgtttgat tggggcaata
2281 ctatatttat ttatatagca taagaactat attctttgaa attataaaag gttcgagcag
2341 gttaacaagc attaaaaata aatgtgtttc atcgtctact tattaccatg attgattgtt
2401 catcaaaata gtaattcgtt agttgggtta aaatcgttgt aaagcagatt tgtttatata
2461 tttaattttt ataattaata ataattaata taagtacgca aggattgatt attgaaaaaa
2521 gaaagaagaa tataatttat ataaattatg gtcaattgtt agtattcata ttaatttttt
2581 taaatgtttt atcattttat aaaggtttat ttttgaaaga ttttttgtat aaaattttag
2641 gaatagttaa taataattta taattttgat tagattgttt tgttaatgct attagatggg
2701 tgtggaaaaa taaaaaaaat aattaatata tatcaataat aaattaaatt aatctattag
2761 tcagaaatgg atgccagccg ttgcggtaat ttctatgctt ttaaatatta tacaattatc
2821 atattaaatt gttaagtgct gatttaacca ataaaaatat aaataatttt tatttgtttt
2881 taaacaccat taggtatatg caaatataaa attatagtaa ttataaatta tattatatta
2941 tatttattca tataattaat aggataatat ttgtagtttt tgataccatg ataaggatta
3001 taaattgaaa gtggtaatat cataatcaaa atttattatt tatattaaat atgtatgtgt
3061 agataaaata agaaattaaa aaggtattgt tgcccaccaa tttttataat aaaaataacg
3121 tgcagtaatt aatatattta taaaaatata ttttagctaa attagaatca atttaataat
3181 tttaagtttt ggttgattaa aagaggagtt tttggaaggt ggggattttc attttgattt
3241 cccagagaac cagagaggcg ggaaccagcg ttttattttt gggggagagc ggagcgcgag
3301 gaaagcccat tttgagcagg agtttttcgg gggggagggg gcatttctgg cggagaacag
3361 agattcttgt ttcggaaggg gagcaggccc gacagatttt tgccaacgca ttcaggaggg
3421 gagccttatt tgaagtgcgc tttctttcaa gagggggaga gaaggggaga aggggaagtg
3481 agaaatttag aattacacgg tgaaattaaa ttttgactaa attaaggttg ccctgttgtc
3541 gtctctatct cctcccaacc cctctcccct tggatccttc cccccaaaac tcctcgatgt
3601 ttcttcccta cccaaatcac ttcagcgttc ccccgctacc caatcatcct cctaccaaac
3661 cccccgcccc ctttaccctc gccccctctc tcaatccaac ttctcctttc tcaatcctcc
3721 tcctctcccc aaccctctcc ccaaaattaa ttcctcgtct aaaattccat tttgtttata
3781 aaaaaaatta agttgatatt aatattatta aatattcaaa attatttatt aatataaaga
3841 aagaatattt tattagtata atattaatgt gtataatgtt aagtcaaatt aaaatgccag
3901 atatgttaaa aaacaggcta ttgtatttat caatagacaa aaaaatatgt ttaaatttaa
3961 atgtatattt ttgtaatatg gttttgtaat gcacaaaatg aataaggaac atttttgtat
4021 attaatttat atgatacaaa aaaacatgac tacatgataa gtacaagagg agacagacga
4081 cagtgtccac agcacccgtt tcagcacagt tggaggagag gggataagat ttattgatga
4141 aatttgtgat ttgcatcgtg gtacagaaaa gttatgtgaa tataaaagtg tagaacaatg
4201 tcttccgatt tcgacaggtt agaagatggg gaagagcagg cattttggag aaggcgaggg
4261 cgacgggcaa gcgaaagatt ttgaaacttt ccgagaaggg ggaacagagg ggtaaggggc
4321 tccggtttag acagaggaat ttcgttgaca aagagacaga agttttgggg cgagcaggct
4381 ttcaggaatg gattcttgat gagggggagg ggattttaaa cagggaggag agagagggga
4441 atcgatagcg gctttggggc agaaagaatt gattatttag aagggggccg cgaggagggg
4501 agagtcgaag gatttttgat ttttgtgaag gagaaggaag ggagcagatt cgaacgggat
4561 agcgagaggg agaagcaagg ggggtttttg ggggttaaaa ggaaaccagt tttagaccaa
4621 agaaaggggg gggccgggaa ttcagctttg tggaacaccc caaagggatt tgaggaattt
4681 ttgggggagc tcgacggcgg gcggagcatt atttgaggag ggcgggagca gaaggctttc
4741 tgaggaaaga ggggaccgag atcgatgaag gttatttttt ggttattgag gattgtttaa
4801 aattgaataa aaaggctttt tggaagggga tttttggggg acaccgccag aggaggaggg
4861 ttttggaaga gtttgttttg agaggaggtt ttgaggggag gggagagagg gaacgggaga
4921 ggaacggacc agagaggaga gttgaggaag gcggttttga aggagagggg aggctttcgg
4981 accaagggaa ggaagggagg ttaagaaaag gaaaaacaat ttgtgaggga gaagggtttt
5041 tggaggggtt ttgggaagag aggggttttg gggaaaccag atgagattgt ttgcagaaac
5101 aaaggggttt ttgggcaaag gaatacaatt tgcagagggg ggagagcgga aggaggaaca
5161 cgggagggaa gacaggattt aggaagcgag agagaggaga ggggaaaggg tttagttgga
5221 atgaagaggt agtttgtagg aagttaagaa taatggttat aaattttata taaaagcgga
5281 gaaaaaagaa agggtctttt aatgtcaggt tgtttatata gaatatatgg ggtaggtttt
5341 agtttaggat tttttatagc attgcaaata atttgtggag tgtgtttagc ttgattattt
5401 tttagttgtt ttatttgttc aaattgatat tttgtattat ttttatgaga ttttgatttg
5461 ggttttgtga taagaagtgt acatatatgt tttacatctt tattatattt actattatat
5521 atccatatat ttaagtcaat aacgttaata atattgtttg acacacatat attagtatga
5581 tttataggtt ttatattgtt tgtatttata ataataatag cttttatagg atatgtactg
5641 ccttgtacaa tgatgtcata ctgaggttta acggtgttta gtaatattat agcaacagta
5701 ccaattttag gtatatgatt atgttattga atttggggaa gtgaatttat aaacgatttt
5761 acattattaa agttacatgt attacatgtg ttattaccat ttatattact aataatatta
5821 attttacatt tattttgtct acattatttt atgagttctg atgcattttg tgataggttt
5881 gcattttatt gtgaaagatt aagtttttgt atgtggtttt atttgagaga tatgttttta
5941 gcattttcaa tattattatg tatgatgtat gttatattta taaattggta ttttgtattt
6001 catgaggaat cttgagttat agtagataca ctaaaaacat cagataaaat attaccagaa
6061 tgattttttt tgtatttatt cggtttttta aaggcaatcc cagataagtt tatgggtttg
6121 tttttaatgg ttattttatt attctcatta tttttattta tattgaattg tatattatga
6181 tttgtgtatt gtagaagttc attattatga ttaacatatt cgttaatatt attttatagt
6241 atatgaatga gtggtttttt agcattatat gtagtattag catatccaat atgaatggaa
6301 ttacaatact gagtattatt attatttttg ttgatagtgt gtaggttaga ttagtttaga
6361 ataaaaaaat aagtattttg atattattaa agtaaaagag gaattttggg cggaagagaa
6421 ggagacagga gaggaaatga aggagaaagg ttttgagagg ggggtttttt gaggggagga
6481 aaaagaattt tgaatttgaa ctatttgttt aagttatggg agagaagcaa ggaggagaaa
6541 agtaggggaa ttttgaggag attcttgggg agaggcgggc gggcgacggc ggttttgaaa
6601 acacccattt ttaggaggat aagaggggag aaaaggggaa atggaattgg gaattgcctt
6661 tgccaaactt ttagaagaaa gagcaggaaa ggttaggggg aggagagaag aaagggaaag
6721 ttgtgatttt ggagttatag aataagatca aataagttaa taatatcaaa gaaaagtata
6781 tatacgctag aacaaatgaa gaataataaa tttttaatat tgataaaaga taattttaca
6841 actcaaaaac caagaaattg ataagaaaaa ataaatatat taacaattaa tctaaaataa
6901 aaaatataaa tgataataag tcatattata aagaaaaagc caatacaaat acaaaggtaa
6961 cttagttgta ataatagaca gaaaactttg ataaaaaatc caaatacaat tggaatagct
7021 ccaatgcaaa gaaagagaca tgcaagtagt aaacttatta aaaagttatt aaaaaaagaa
7081 aaaaatatga agttgattaa aaaatagttt tcattgtatt taaagtcaaa aatattatat
7141 ataataaaaa aatagtatat aataataagt aatactaaac ttatactata aattaagtga
7201 aaatttaaat ataaataaaa gatataattt tttgttgaaa taaatattag gaataaaaag
7261 caaaaattat tcacacttaa cacaaatagt aaactaacga tagcaaagct gtttaatcca
7321 attaaaacgc atgtacaaga ttgaaataat agaagtttga tgaataaaat ataaaaataa
7381 atgaagctaa ttagtagaat tattaatata aaacaaaaca aaatataaaa agttaacata
7441 taaataaaaa taaagacacc aagtctaata taaagttgct ccataaacaa aattaaaaag
7501 gcgatgtata atttgaataa aattaataat gtgtaaaata ggcataaaat tccaagtcat
7561 tcttcatcaa aaactaaaaa acaaaaatca cataggaaaa aacagtagtt taatatcata
7621 aaatataata atataaataa taatataaaa tttattaagt ttaacatgta gtaatatcat
7681 agaactaaaa ttttatatcc aaatctactg gacattaata ataaaaagag caataagcta
7741 aatatttcaa agaggattga tataataata atatgattaa taaatataaa taagaatata
7801 ataatgtatt gaataataat aataatgaat aaaaatctgg tatcgaatga tagaaagcaa
7861 aaaaataatg taaagcaaaa taagaataag agtataaaga tgaaacaaat ataagaatct
7921 aataatgtta ttcaaaatag gttaataatt aataatcaga gtaaatcaaa gcttagtaat
7981 gttagtgtag tataatcaca taagataata aagctgtaga taataagaaa tataaatatg
8041 tgtatgatat ataaaaacaa ggattttttg ggggtttagg gacagagggt ttatttttga
8101 ggattttagg aggagaaaag ggatgggaaa cagaaggaca taagaaaagt ttcgttatta
8161 gattaaaaaa gtatgcaaat aatttttgta atagcaataa atgaaaaatt aatgaatccc
8221 attgtaaata aaaaaagtaa tataaatgtt tgtgcagttg taatttttaa tctacagcat
8281 ataacacgtg gtataagaaa acctagaatt agtataagaa tagatttaaa gcatataaaa
8341 aggccaccaa aacataagca gctaaataat atagtagtta gtaataaatg attaatttca
8401 aggacggagt atatgacaaa aaaaatacca gataattcag taacaaggcc agcaacaagt
8461 tcactttcac attctagata atcaaagggt aaacgtaatc catcaagaag cagtccaatt
8521 caaaatagac aaatgaataa aagaccaagt ataaagcaat tttgtaaaga aagttgactt
8581 atacaaatat cttttatgcc aaagaaacaa aagtagtcta gtatgtatat acaataaagt
8641 agaattaaaa tggaacattc agatagaata ctaaaaaata aagttctcat ggcagctagg
8701 taaataaagc agcttgaaaa taaaaaacaa ccaacgaaaa aaatgcaaaa tacattagaa
8761 aataaatgaa atcctaataa aaaaagaagt gtaaaacctt tgtcaaatat tattatgaat
8821 ccaagtggga aaaagaacca aggaaaaaaa atacaaaaag ctgtaatgaa taaactagat
8881 ataaataata tagagtcaac accaatcaca aataatgtaa atttaacaaa taatttaact
8941 ccatcagtaa taggagtaag aagaccaaat aaaaaaagtg caggtcctat tctgaattgc
9001 acaatagcta aaattttacg ttcacataaa ctaacatacc cacataagac agataaaacg
9061 agtataaata taacaataag tatgcatata tctaaatgta ataataacaa atgagtttta
9121 tattaacttt ttgaatgata tttttaatgg attcaataat tgtattaata tctttttcaa
9181 tatttctatc tgtatgaata tgtgcattga ttatagcaac agtattaact gtaacaaaaa
9241 taaataatat atattgtaca tgagatttta tatcatcaaa atttatagat acatattggt
9301 ttgtacttgg aatgatgttt atattgtgtt tattgttaag gttgtgtttg ttgttgtatt
9361 ttagttgtat aaattttgtg agttttgatt tgtgtaaagt aataggtttt cagtgatatt
9421 gggtatattt tttatttgga gaaaccacga tatttagtaa tttaatatta gaaagtgatt
9481 atttaatagg agatttaaga atattacagt gtaaccatgt attgacattg ttaagtttgg
9541 ttatttataa attatgagta tctgcagtag atgtaataca ctcatttaca atatcaagtt
9601 taggtataaa agtagagaac ctggtaggtg taatgaaata attttgtttg ctacaaataa
9661 cgcaactctt tacggacaat gtagtgaatt gtgtggtgta ttacacggtt ttatgcctat
9721 tgtaataaat tttatataga aaggtatata atctataatg aaaggggatt ttaagattgg
9781 ctttgattga gtcgtgtttt tgatttgtta tgtattagaa catatgattt tatattgtga
9841 tggtttgatc tagattttat attatatgat tttgtattcg attttgttgt atgtattaca
9901 tttatattta tatttgtttt aggttttttt attagaattt tttttagttt tgtgtttgta
9961 ttgttattta taacattttt tggaatttgt tcattaacaa tgttatttac agggtattat
10021 atatattata tatatatatt atataatttt atatgttttt tttttgcatt tggtataaat
10081 tttttgatat attatatcga gtttttcata tttataacat tccatatatt tttcgatttt
10141 ataagttttt ctaattatat atataattat tttggaatat tgtatatgtt taatgtaatg
10201 ttttgtgcat atttattttg tttattttat tttgtgatat attttttatt ttgttttata
10261 ttttttgtaa tacgatgttt atttatagta ataatggatt ttttattttt taattttgat
10321 atatttgtat ctatattatt atgtgatata gtatatttag attttataag tttattatta
10381 ttatatttta attttatatt taattttatt tatggatttt ttagttttgt gataatttta
10441 ggtttattat ttttattgtt atttttagta ataaatttat tttttggatt tacattttta
10501 gtatatggta tacaaatcat attattatat tatgtatatt gattatatat gatatatagt
10561 agaagttgtt atatattgat gccagcaata ttaatatttt ttaagtttat atattttgat
10621 gtattctttg tgtttgtatt tattttaatt ttatttatta tatcattttt tagttttttt
10681 ttaaaagatt ttttattttt atcattatat tttgatatat tcggatcatt atataattac
10741 gatatattat catatagtat attttattat caaaataatc agttttgttt aacacagtta
10801 ttatcaattt atatataaaa gaataatagg aaggcttgtc aaaaaaaaat ataaaatacg
10861 aagcaaaagc aaagtattat taataaatag tcaagtatta tatgcgcaaa atcaataaca
10921 agtaaataaa tagccataca aactggtact catgtataaa aatagaagaa tatagataag
10981 ctatatgtaa acaaattaat aaaaaataaa cagtaatctc agaataatat aacattaaac
11041 aaacaacagc aaaatataac taaaaaagtc aacaaaagca taccatacaa tgtaaacgca
11101 cttcaaaata aaaagctgat aggataatca gaaattcttc ttggaaaagc aaacattcct
11161 aagctatgta aaggaaaaaa aaccatatta gaaccaaatc ataatgtgga aatgaagaaa
11221 aataatcaaa atgtgtgaag ttcaatagga attcatttca tgagaaaatg aaaaaaccca
11281 ccaaaaaccc ctacaacagc accaagtgat aaaacatagt ggaaatgtac aacaaaataa
11341 gtatcatgca tcaaaatatc aataccaaca tttgatagaa ataagccagt taatccacca
11401 gcaagaaaca taagtataaa catatatata aaataaattt caaaacaaat acacatatct
11461 gtgaataaga agctatagat tcaattaaat aatttaatgc atgtaggtaa gcctattagt
11521 acagtaatac ttccaaaata agctctagaa tcaacatcca taccaacaac aaacatgtga
11581 tgcgctcaaa caaacatacc taatacagat atcagtagca tagaataaat catagcgacg
11641 gaactaaaaa cgcatctaaa acttgtaact tcaataatag tggaaactaa tccaaataca
11701 ggtagaatta tgatataaac ctctggatgt ccaaagaacc aaaataagtg ttgaaataaa
11761 actagatctc cacctccaac aacatcataa aatgatgtgt taaaatttct atcgcataat
11821 aataatgtaa ctccaccagc caaaacggga agtgtaataa tcaaaagtat ggatgtcaac
11881 aaggcacctc aaataaaaag tgttcaaata agaaagctaa aatattttcg tctacagcaa
11941 aaaattgtac ctacaacatt aatggaattt aatatactag atataccaag aaaatgcaca
12001 gagaaaatga taaagtcaca tgctaagcta gaatgaaaat caatacaaat caacgtagga
12061 tacaaggtcc aaccaacccc cataccctct tcagtcaaaa acccacttac taagcaacca
12121 aatcctccaa taaacattca aaagctcata ttatttatac gaggaaatac catatcggga
12181 aacccaacca tgacgggcgc aaaatagttt gtaaacccac ccatagttat aggcataata
12241 aaagcaaaaa ccataatcaa cccatgtgaa gtaatgagta cgttgtaaaa ctgataatca
12301 ccaaataaaa ctccacaacc aattagagaa agttctaatc taataaataa ggagtaaata
12361 taaccgataa atccacataa aatagcaact aaaagataac aaattccaat cattttatga
12421 gaaacactta agcacacaag acatagaaaa aacattttat aaaaccaaaa taaaaacaaa
12481 actatttctt cgcaattata aaccaaaatt ccatcaaccc cctctccccc tcctccccac
12541 aaaaccccac actttctccc caactaaaac cccccaatca aactcccctt caatttcgtc
12601 ctcttctaaa cccaacttcc ccaaatcccc cttcctctcc cccacaaacc cccctttcct
12661 catagatcaa tcccaaccaa acttaaagcc cctttttaat aaatacacaa agataacaat
12721 aaattataag aaggaaattt atagaaagca caaaaataaa attaaattag agtaattgaa
12781 tgttaaaatt aaatttaata tgtataaatt ttatattgtt aattgttaca ataatatata
12841 tatatataaa ctatagtttt tgtattggaa tagaaatcaa ttatgtatat gtaaatatat
12901 atttaaatta catcagtcta tgatttgtat tttttatggg aattattatg tacatattaa
12961 tatttttatt atcaaagaaa tgtgtatcat ataataaata tttttacata gtaatgatat
13021 atatgtatat atatattaat gtagtgttaa taataatatt agatgatttt atgtgtttta
13081 tgatagcctt cgaaagtcta tttttcccta tatgtctagt aagtttattt tttaatttta
13141 ataatagatt tatttttgct atattctatc ttataatatt tagttcagtt agttcagtgg
13201 tatgtataat tatatgtata atagtaatat ctcatttcaa cattataaat ttacaggctt
13261 ttattgatgt atgttatttt gatagtttgt attcggcaat ttttatatga atattattat
13321 ttataatgtt cgctataaaa tacccaatct gaccattcca tgtgtgacta ccagagatgc
13381 atgtagaggt aaatacagaa atgagtgttt tattagcaag tattgtgctg aaaataggtt
13441 tttttggtgt atacaaattt ttatttatcg catttaatac gatatcaata tgatttttag
13501 gttttataga tagtgtaatt gtgttgggtt tagtatttat agcaatgtca ctaatatttt
13561 tatcagacta caagaaaata atagcgaatt gatcaataat acacacgggt ataggattaa
13621 tattattatg acataatgac attttgtttg taggtttact aatattatgt aatctagcac
13681 atatactaag ttcatccttt atgtttattg taataggata tatgtacgac aattatggtg
13741 taagaatttt tttattgtta atttcatttt ttggtattag tatatgaagt tcattgtttt
13801 tatgtttatt tttatttaat atagatttcc cgtttatgtt attattttat gtagatatat
13861 ttattttgta tggtttgata tctatatcat ttatatatat aataagtttt tatataataa
13921 ctttaacgat atttttatca tcaatataca tctatatgtg tttaagtttt tattcatttg
13981 tatggttgga taaatatctt agacttgatg ttagtataaa tgatatatat gtatttatgt
14041 caatatcaat atcaactata gtattttatt attttatata tttattaata taatatgtat
14101 aatacaacaa acaaatctct ttaccccctt cagtgatccc tccccatcaa aacttctccc
14161 cccaaaaccc atctcccatt caccccaaac ctatggtttc tccaacactc cattcctgtt
14221 cacaccgtga ttcttctcaa ccccgccccc cgctctgctc tctcctttta aaatccctaa
14281 tacacttttg ataacaaact aaagtaaaaa ggcgaggatt ttttgagtgg gactggagag
14341 aaagagccgt tcgagcccag ccggaaccga cggagagctt cttttgaata aaagggaggc
14401 ggggaggaga gtttcaaaaa gatttgggtg gggggaaccc tttgttttgg ttaaagaaac
14461 atcgtttaga agagatttta gaataagata tgtttttaat atttttttta ttttttataa
14521 tgtttgggtt tatatcaggt tcatttatgt ttggtaggaa ttttctaagt ttttgattat
14581 ctttagtaat gataatattt attgtattgt gtatgatatt tagtttttta atggtatcag
14641 tatgtttata cggttattat tattacgatt tttgtttaat actaatgtta gatttttgtt
14701 ttatatgatt aacatacgta tgttcaggtt tttatatgtt tataatgtta ttgataaata
14761 tggtattttg ttttatagta ttttacgcat tttattatat gtattttgat atgttgttag
14821 ggcgtttttt gattatattt tgaatatttg ttgtgtgcat gaatttattc atcctatcat
14881 atgatttttt aacagcttac tgcggatgag aattattagg gttattctca ttttttttaa
14941 tttcatattt ctgataccgt ttttttgcat taaaatttgg ttttaaagct ttttttatag
15001 gtaaaatagg agatgtgtta ttaatattcg ctttttctat aatattttta tcaaatggtt
15061 tttgtatgac aactttttat tttttaaatt ttttttgtat ggattattat tatatagaat
15121 tttctatatg tttgttagta ggatgtgcgt tcacaaaaag tacacaattc ggcttacata
15181 tatgattacc agatgctatg gaaggaccta tcccagtatc agcattaata cacgcagcta
15241 cattagttgt ttgtggaata atattattaa gttttgttta ttgatgtttt gatttttgat
15301 ttagttattt ttataatttg ataggatggt ctacattaat tttaatatta atgacattgt
15361 gtgtgtttta taattttgac gtaaaacgat acgtagcgtt cagtacaata tgtcaaatta
15421 gtttttctat gttttgttgt ctgtgtatag atatatatat aggtagttta tttttttgtt
15481 accatatgtt ctacaaagca acattattta tagtattagg tatatgaata catatatttt
15541 ttgggttaca ggatttaaga tgttattttt ttatgtattt ttgtggttgt gtgttagcgc
15601 gtttgttatt aatattcgca atattaaact catgttcaat ttgattttta tgtggttttt
15661 attgtaagga tatgttatta gctttattga tgttattatc attttataat ataatagaat
15721 ttttgtttat aagtataatt tttatatttt ttacaatgat ttataattat tttttgttat
15781 tttttttgat gtttgtgttc aaatgttttt gtttggttga ttgtttattt ttattatttg
15841 attatgaatg ttgtttagta tattgtttga taagtttgta tatgtgtatt ttaagtatat
15901 tttttataat agattttgta tgtatatttg tattttcaag ttattgtgta ttttgatcat
15961 tttttttaaa tttttataat ttttttgata tagcaatttt tgtggttttt ttaatattat
16021 cagtaggatt tttatattat ggttgtttat ttttttattt tttcaatata gattgcataa
16081 tgttgttttg gagaattttt tttgtaataa taattttagt agtatttatg atattttgtt
16141 gttgatattt tgtttgtatg atcatattta tgttattatt tgtatgaaat tttgttatat
16201 attttagata taatttgaaa tattgtttat ttttttgtat tttgtgaata ttgtatgtat
16261 aaatagtata atcaaaagta aaaaaagtaa agaaaccaga ttagatttgt aaaaaagtca
16321 aaatatttta taatattaca actattatat acatatttca aagaaaaata taagttgcat
16381 ttagaaataa aaaagtagta gttaaaattt ttgtaaaata aaaacaaaac aaaacaaaac
16441 aaaacaaaac aaaacattca tagaaaatca aagttcctag aaaattaaaa agtgtttaat
16501 aataaaaatt aattttaaat aagttaaaga agaaaataaa tattaatata taaaaccaca
16561 aaatatatgg gttgaaattt agaaaaaatt gtaaattatt ttagtttttt gtaaaaataa
16621 aacaaaaatt aaaaaataaa acaaaaatta aaaaataaaa caaaaaaaac aaaaaataag
16681 ttaaaattaa aaaaataagt caaaattaaa aaaaaataag tcaaaattaa aaaaaaataa
16741 aacaaaatta aaagaagtaa accaaacccc ccattatttt ttccataaaa ctccttgtaa
16801 attacaattt ttgtgttata aaataaataa aataagtgat agaagagaga aaattgtaaa
16861 ttacattaat gtaaaattaa gaattgctaa atatgggttg aaaaattgaa aaatttgtaa
16921 attagtttaa tttttgtaaa aaacagaaca aaagaccaaa aaataagtca aaaaaccaaa
16981 aaataagcca aaaaatcaaa aaataagtca aaaaatcaaa aaataagcca aaaaaccaaa
17041 aaataagcca aaaaatcaaa aaataagcca aaaaatcaaa aaataagccc aaaaattcaa
17101 aaaataagcc cagaaattca aaaaataagc caaaaaatca aaaaataagc ccaaattaaa
17161 aaaaaataaa acaaaattaa aagaaacccc ccatattttt cataaaactc cttgtaaatt
17221 acaattggca ttataaaata aataaaataa gtgaaagaag agagaaaatt gtaaattaca
17281 ttaatgtaaa attaagaatt gctaaatatg ggttgaaaaa ttgaaaaaat ttgtaaatta
17341 gtttaatttt tgtaaaaaac aaaacaaaaa atcaaaaaat aagccaaaaa ttaaaaaaaa
17401 agccaaaaat taaaaaaaaa gccaaaaatt aaaaaaaaag ccaaaaatta aaaaaaaagc
17461 caaaaattca aaaaataagc caaaaaatca aaaaataagc caaaagttca aaaaataagc
17521 ccaaaaattc aaaaaataag ccaaaagttc aaaaaataag tcaaaagttc agaaaataag
17581 ccaaaaatta aaaaaataag cccaaattaa aaaaaaataa aacaaaatta aaagaagcaa
17641 ccctctttcc ataaaactcc ttgtaaatta caattggtat tataaaataa ataaaataag
17701 tgaaagaaga gagaaaattg taaattacat taatgtaaaa ttaagaattg ctaaatatgg
17761 gttgaaaaat tgaaaaattt gtaaattagt gtttaatttt tgtaaaaaac aaaacaaaaa
17821 aacaaaaaat aagtcaaaat taaaaaaaaa aataaaacaa aattaaagaa aaaaaaccct
17881 ccatttccta agacttctat aaaattgaaa attaccaatt aaattagtat tataaaaaaa
17941 taaataagtg aaagaagagg aaaattgaaa attacattaa taaaaaatta gaaatggcta
18001 aatatgggtt gaaaaattga aaaatttgta aattagttta atttttgtaa aaaacaaaac
18061 aaaaaaacaa aaaaacaaaa aaacaaaaaa acaaaaaata agccaagact tcaaaaaaat
18121 aagctaaaaa ttcaaaaaat aagctaaaaa tttaaaaaat aagctaaaaa ttcaaaaaat
18181 aagcccaaat taaaaaaaaa taaaacaaaa ttaaaagaag cagccccttt ttcatatttc
18241 cataaaactt cttgtaaatt acaattggta ttataaaata aataaaataa gtgaaagaga
18301 gagagaaaat tgtaaattat attaatgtaa aattaagaat tgttaaatat gggttgaaaa
18361 attgaaaaat ttgtaaatta gtttaaaatt tttgtaaaaa ataaaacaaa aaagcaaaaa
18421 aacaaaaaaa ataagtcaaa attaaaaaaa aataaaacaa aattaaagaa agcaaaaatc
18481 ctccattccc taacactttt ataaaattgt aaattaccaa ttaaattagt attataaaaa
18541 aataaataag tgaaagaaga gaaaattgta aattacatta atgaaaaatt agaaattgct
18601 aaatatgggt tgaaaaatta aaaaatttgt aaattagtct aatttttgta aaaaacaaaa
18661 acaaaaaaat caaaaaaata agtcaaaaat taaaaaaata agtcaaaaaa ttaaaaaaat
18721 aagtcaaaaa attaaaaaaa taagtcaaaa aaattaaaaa ataagtcaaa aaaattaaaa
18781 aaataagtca aaattaaaaa aataaaacaa aattaaaaga agcaaaacaa aaccctccaa
18841 ttttccacaa accctcctta caattggtat tataataagt gaaagaaaaa ttgtaaatta
18901 cattaatgca aattagaaat tgctaaatat gggttgaaaa attaaaaaaa tttgtaaatt
18961 agtttaattt ttgtaaaaaa gaaaacaaaa aaatcaaaaa ataagctaaa aattcaaaaa
19021 ataagccaaa attaaaaaaa aataaaacaa aattaaaaac ctatatttcc ataaaacccc
19081 tttaaattac aatattggta ttataaaata aataaaataa gtgaaagaag agagaaaatt
19141 gtaaatcaca attaacgaaa aattagaaat tgctaaatat gggttgaaaa attgaaaaat
19201 ttgtaaatta gtttaatttt tgtaaaaaac aaaaaaaaac aaagaaataa gtcaaaaatt
19261 aaaaataaat aagtcaaaaa ttaaagaaag caaaaaaaat ccaccattcc ctaagacttc
19321 tataaaattg taaattacca attagtatta taaaataaat aagtgaaaga agagaaaatt
19381 gtaaattaca ttaatgaaaa attagaagtt gctaaatatg agttgaaaaa ttgaaaaatt
19441 tgtaaattaa tctaattttt gtaaaaaaca aaacaaaaaa atcaaaaaaa taagccaaaa
19501 aatcaaaaaa taagcaaaaa ttaaaaaaaa taagtcagaa aattaaaaaa ataagtcaga
19561 aaattaaaaa aataagtcag aaaattaaaa aaataagtca gaaaattaaa aaaataagtc
19621 agaaaattaa aaaaataagt cagaaaatta aaaaaataag tcagaaaatc aaaaaataag
19681 tcagaaaatc aaaaaataag tcaaaattaa aaaaaataag tcaaaattaa aaaaaataag
19741 tcaaaaatta aaaaaataag tcaaaaaatc aaaaaataag caaaaattaa aaaaaataag
19801 tcagaattaa aaaaaaataa gccaaaatta aaagaagcaa aacccccatt ttccacacca
19861 acccccctta aattacaatt ggtattataa taagtgaaag aaaaagaaaa ttgtaaatta
19921 catgaatgca aattagaaat tgctaaatat gggttgaaaa attgaaaaat ttgtaaatta
19981 gtttaatttt tgtaaaaaac aaaacaaaaa acaaagaaat aagtcaaaat taaaaaaaaa
20041 taaaacaaaa ttaaagaaag caaaaaaaaa aaatcaccat tccctaagac ttctataaaa
20101 ttgtaaatta ccaattagta ttataaaata aataagtgaa agaagagaaa attgtaaatt
20161 acattaatga aaaattagaa gttgctaaat atgagttgaa aaattgaaaa atttgtaaat
20221 taatctaatt tttgtaaaaa acaaaacaaa aaaatcaaaa aaataagcca aaaaatcaaa
20281 aaataagcaa aaattaaaaa aaataagtca gaaaattaaa aaaataagtc agaaaattaa
20341 aaaaataagt cagaaaatta aaaaaataag tcagaaaatt aaaaaaataa gtcagaaaat
20401 taaaaaaata agtcagaaaa ttaaaaaaat aagtcagaaa attaaaaaaa taagtcagaa
20461 aattaaaaaa ataagtcaga aaatcaaaaa aataagtcag aaaaccaaaa aaataagtca
20521 aaattaaaaa aataagccaa aattaaaaaa ataagtcaaa aattaaaaaa aataagtcaa
20581 aaaatcaaaa aataagcaaa aattaaaaaa aataagtcag gattaaaaaa aaataagcca
20641 aaattaaaag aagcaaaacc cccatttccc acaccaaccc cccttaaatt acaattggta
20701 ttataataag tgaaagaaaa agaaaattgt aaattacatg aatgcaaatt agaaattgct
20761 aaatatgggt tgaaaaattg aaaaatttgt aaattagttt aatttttgta aaaaacaaaa
20821 caaaaaacaa agaaataagt caaaattaaa aaaaataaaa caaaattaaa gaaagcaaaa
20881 aaaatcacca ttccctaaga cttctataaa attgtaaatt accaattagt attataaaat
20941 aaataagtga aagaagagaa aattgtaaat tacattaatg aaaaattaga agttgctaaa
21001 tatgagttga aaaattgaaa aatttgtaaa ttaatctaat ttttgtaaaa aacaaaacaa
21061 aaaaatcaaa aaaataagtc aaaaattaaa aaaaataagt caaaattaaa aaaaataagt
21121 caaaattaaa aaaaataagt caaaattaaa aaaaaataag tcaaaattaa aaaaaaataa
21181 gtcaaaaatt aaaaaaataa gtcaaaaatt aaaaaaaata agtcaaaaaa tcaaaaaaaa
21241 taagccaaaa aatcaaaaaa taagccaaaa ttaaaaaaaa tcagccaaaa ttaaaagaag
21301 caaaaaaccc ccattttcca caacaacccc ccttaaatta caattgatat tataataagt
21361 gaaagaaaaa gaaaattgta aattacatga atgcaaatta gaaattgcta aatatgggtt
21421 gaaaaattga aaaatttgta aattagttta atttttgtaa aaaacaaaac aaaaaatcaa
21481 aaaattgtag attagttaag ttttttttgt aaaaacaaaa taaaaacaaa ataaaaacaa
21541 aataaaaaca aaataaaaac aaaataaaaa caaaataaaa acaaaataaa aacaaaataa
21601 aaacaaaata aaaacaaaat aaaaacaaaa taaaaacaaa ataaaaacaa aataaaaaca
21661 aaataaaaac aaagtaaaaa caaagtaaaa acaaagtaaa aacaaagtaa aaacaaagta
21721 aaaaatttga aaatttgatg tttaaaaaaa atttattttt ttgaattttt tttgaatttt
21781 tttgcaaggt tttaaaaatc gatatttaat attttaaatt ttttgcaaaa atttaaaaat
21841 taaaaaattt gatgtttttg agtttttttt acaaaatttt aaaattaaaa aatttgatgt
21901 ttttattcaa ttttcagagt aaaaaaataa aaaatttgat gtttttggaa ttttttgtga
21961 aatttaaaaa ttaaaaaatt tgatgttttt ggtttttttt tttggtgggt ttttaaatta
22021 aaaatttact ttttgaaatt tttcaaattt aaaagttgat ttattttttt attcatttta
22081 ttataaagcc taaaagtatc ccgttggcac aaaatgcaaa aaatttgact tttttttgaa
22141 tttttttgca aaatttaaaa ataaaaattt gacttttttc gatttttttt gtaaaattta
22201 aaaataaaaa aatttgatgt ttttgaaatt ttttttgtga aactttaaaa ttaaaaaatt
22261 tgatgttttt atccaatttt cagagtaaaa aattaaaaaa tttgaatttt tttaaaattt
22321 tttgcaaaat ttaaaaatta aaaaatttga tgttttttgg aattttttgt gaaatttaaa
22381 aattaaaaaa tttgaatttt tttaaaattt tttgcaaaat ttaaaaaatt aaaaaatttg
22441 atgtttttga ggtttttttg tgaaatttaa aaattaaaaa ttcgattttt attcaatctc
22501 aaagaaaaaa aaaaaaataa ggagtttgac ttttttgaat tttgtttgtg aggttcatag
22561 aggagaatgg ttcaagaatg taattttttc gtttctccat tattactaag ttcaattgag
22621 aaggacaaaa gcaaaagatt gtgtaagtgg aggatgtagt gggaagtaag taactagtta
22681 ggcatagtat aataataata tatatatata tatataataa gatataagta tgtagagtaa
22741 gtatattata tgtaagtgta tatagatagt taaaagttat atagtgtaaa gtatggatag
22801 tgtaatttaa gatagtataa tttaggaaat taaacatgat aataatggag atttatagtt
22861 tacactatta ttgtgttttt aaaaaaataa atttacaaag taaatttatt tttgtaaaaa
22921 cactattgca cgcgaaattt tttatgggat gggtgagtcg ggtatgggtt taatgggtaa
22981 ttttaaagca agtaattatg aattaggata agaaca
//