Gene: CR4 (G4) Species: Trypanosoma brucei Notes: (1) Two sites of variation in the 3' end of the editing domain are either 1U or 2U at nt 545 of mRNA (2) BF and PF T.brucei have different consensus sequences (nt 231 to nt 301). The fully edited sequence only occurs in BF cells. (3) In the DNA sequence there is an A present after nt 100, a T absent at nt 105 and a G absent at nt 109. (4) In the edited RNA sequence there is an A present after nt 201, and a G absent at nt 212. 1 ---------+---------+---------+ - - -- -- - --+--- 43 DNA TAATTTATTGTTATCTTTGTGTATTTATTA A A AA GG G GCTTTA RNA-ed UAAUUUAUUGUUAUCUUUGUGUAUUUAUUAuuAuuuuAuuuuAAuuuuGGuuGuGC Auuu 1 ---------+---------+---------+---------+---------+------ ---+ 60 44 - ----- +--- - - ---- +------ - -- + - - - 73 A GTTTG GTTG G G ATTG ATCTATG A GG A A A G uuuuuuuuuuuAuuuG GuG UGuuuGuGuuuuA UGuA C A GuuuAuGGuAuAuuuuAuuGuu 61 ---------+------ --- +---------+-- ---- - - -+---------+---------+ 120 AA M Y S L W Y I L L L 1 - - - - - - - - - + 10 74 - - - - --+-- -- - --- - + - - - - -- 96 G G G G GTTTG TG G GGG A G A G G A AG GuuuuGuuuuuuGuuuuuGuuGUUUGuuUGuGuGGGuAuGuuuuAuuuGuuuuGuuAuAG 121 ---------+---------+---------+---------+---------+---------+ 180 F C F L F L L F V C V G M F Y L F C Y S 11 - - - - - - - - - + - - - - - - - - - + 30 97 - - - + ------- - -+ - ---- - ---+- - - -- 125 G G G G TTTGTGG G GA A GTTG G GTTTA G A AG uuGuuuGuuuuuuuuuGuuGuUUUG GGuuGuGAuuuuuuAuuG GuGuuuuG AuuGuAuAG 181 ---------+---------+----- ----+---------+--- ------+- --------+ 240 C L F F F V V L G C D F L L V F W L Y S 31 - - - - - - - - - + - - - - - - - - - + 50 126 - - --+- - -- --- - - + - - 142 A G GACG A AA TTG A A G G G uuuAuuuuuuuuGuGACGuuAuAAuuUUGuuuAuuuuuuuuuuuuAuuuuGuuuuGuGuu 241 ---------+---------+---------+---------+---------+---------+ 300 L F F L W R Y N F V Y F F F L F C F V F 51 - - - - - - - - - + - - - - - - - - - + 70 143 - - ----- + ---- - -- --+--- ---- - 168 G A GTTTG A TTGG G GG GTTTTA GTTG G uuuuGuAuuG UUGuuuuuAuUUGGuuuGuuuGGuuuuuuuuuG UAuuuuuuGUUGuGuuu 301 ---------+ ---------+---------+---------+--- ------+---------+ 360 F V L L F L F G L F G F F L Y F L L C F 71 - - - - - - - - - + - - - - - - - - - + 90 169 - + - -- - - - -- -+ ---------+ - 191 G G A GA A A G TG TG GGGTTTTGTG G uGuGuuAuuuuuuGAuuuAuuuuuuAuGuUGuuuuuUGuuuuGGG UG GuuuuuuuGuuuu 361 ---------+---------+---------+---------+----- -- --+---------+ 420 V L F F D L F F M L F F V L G G F F V F 91 - - - - - - - - - + - - - - - - - - - + 110 192 - - - - - - - -+ - - - - -- - 207 G G A G G A G GG G G A G AG G uGuuuuuuuuuuuuGuuuAuGuuuGuuuuuAuuuGuGGuuGuuGuuAuuuuGuuAGuuuG 421 ---------+---------+---------+---------+---------+---------+ 480 V F F F C L C L F L F V V V V I L L V W 111 - - - - - - - - - + - - - - - - - - - + 130 208 - - +--- - -- - - -+--------- +- ------ - -+- -- -- 245 G G GTTG A TG G A ATTTTGGTTTA TA ATTGCG A AGA AA TA GuuGuuGUUGuuAuuUGuGuAuA GGUUUAuuUAuA UGCGuuuuuuAuuuuAGAuAAuUAu 481 ---------+---------+--- ------+----- ----+---------+---------+ 540 L L L L F V Y R F I Y M R F L F * 131 - - - - - - - - - + - - - - - - 146 246 ----+---------+---------+---------+---- 283 GTTTTGTTTTTATTTTGGTTTTATAAAATGTTTTTTCT G G UA UUGGUUUUAUAAAAUGUUUUUUCU 541 - - -- -----+---------+-------- 568