LOCUS L. tarentolae maxicircle (revised) 20992 bp DNA circularINV10-APR-1996
DEFINITION Leishmania tarentolae kinetoplast pre-edited mitochondrial maxicircle DNA complete transcribed region and flanks.
ACCESSION M10126 J02707 M10127 M11022 M64690 N00030
NID g1256945
KEYWORDS 12S ribosomal RNA; 9S ribosomal RNA; NADH dehydrogenase; cytochrome; cytochrome oxidase; oxidase; ribosomal RNA.
SOURCE Leishmania tarentolae DNA.
ORGANISM Kinetoplast Leishmania tarentolae
Eukaryotae; mitochondrial eukaryotes; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmania.
REFERENCE 1 (bases 2213 to 6561; 9425 to 16392)
AUTHORS de la Cruz,V.F., Neckelmann,N. and Simpson,L.
TITLE Sequences of six genes and several open reading frames in the
kinetoplast maxicircle DNA of Leishmania tarentolae
JOURNAL J. Biol. Chem. 259 (24), 15136-15147 (1984)
MEDLINE 85079995
REFERENCE 2 (bases 1582 to 2415)
AUTHORS de la Cruz,V.F., Lake,J.A., Simpson,A.M. and Simpson,L.
TITLE A minimal ribosomal RNA: sequence and secondary structure of the 9S
kinetoplast ribosomal RNA from Leishmania tarentolae
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82 (5), 1401-1405 (1985)
MEDLINE 85140304
REFERENCE 3 (bases 1 to 1665)
AUTHORS de la Cruz,V.F., Simpson,A.M., Lake,J.A. and Simpson,L.
TITLE Primary sequence and partial secondary structure of the 12S
kinetoplast (mitochondrial) ribosomal RNA from Leishmania
tarentolae: conservation of peptidyl-transferase structural
elements
JOURNAL Nucleic Acids Res. 13 (7), 2337-2356 (1985)
MEDLINE 85215618
REFERENCE 4 (bases 18234 to 20992)
AUTHORS Muhich,M.L., Neckelmann,N. and Simpson,L.
TITLE The divergent region of the Leishmania tarentolae kinetoplast
maxicircle DNA contains a diverse set of repetitive sequences
JOURNAL Nucleic Acids Res. 13 (9), 3241-3260 (1985)
MEDLINE 85215682
REFERENCE 5 (sites)
AUTHORS Simpson,A.M., Neckelmann,N., de la Cruz,V.F., Muhich,M.L. and
Simpson,L.
TITLE Mapping and 5' end determination of kinetoplast maxicircle gene
transcripts from Leishmania tarentolae
JOURNAL Nucleic Acids Res. 13 (16), 5977-5993 (1985)
MEDLINE 85297791
REFERENCE 6 (bases 6481 to 9501; 16391 to 18233)
AUTHORS Simpson,L., Neckelmann,N., de la Cruz,V.F., Simpson,A.M.,
Feagin,J.E., Jasmer,D.P. and Stuart,J.E.
TITLE Comparison of the maxicircle (mitochondrial) genomes of Leishmania
tarentolae and Trypanosoma brucei at the level of nucleotide
sequence
JOURNAL J. Biol. Chem. 262 (13), 6182-6196 (1987)
MEDLINE 87194837
REFERENCE 7 (sites)
AUTHORS Feagin,J.E., Shaw,J.M., Simpson,L. and Stuart,K.
TITLE Creation of AUG initiation codons by addition of uridines within
cytochrome b transcripts of kinetoplastids
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85 (2), 539-543 (1988)
MEDLINE 88124876
REMARK Erratum:[Proc Natl Acad Sci U S A 1988 May;85(10):3540]
REFERENCE 8 (sites)
AUTHORS Shaw,J.M., Feagin,J.E., Stuart,K. and Simpson,L.
TITLE Editing of kinetoplastid mitochondrial mRNAs by uridine addition
and deletion generates conserved amino acid sequences and AUG
initiation codons
JOURNAL Cell 53 (3), 401-411 (1988)
MEDLINE 88210465
REFERENCE 9 (sites)
AUTHORS Shaw,J.M., Campbell,D. and Simpson,L.
TITLE Internal frameshifts within the mitochondrial genes for cytochrome
oxidase subunit II and maxicircle unidentified reading frame 3 of
Leishmania tarentolae are corrected by RNA editing: evidence for
translation of the edited cytochrome oxidase subunit II mRNA
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (16), 6220-6224 (1989)
MEDLINE 89345635
REFERENCE 10 (sites)
AUTHORS Blum,B., Bakalara,N. and Simpson,L.
TITLE A model for RNA editing in kinetoplastid mitochondria: 'guide' RNA
molecules transcribed from maxicircle DNA provide the edited
information
JOURNAL Cell 60 (2), 189-198 (1990)
MEDLINE 90124629
REFERENCE 11 (sites)
AUTHORS Sturm,N.R. and Simpson,L.
TITLE Partially edited mRNAs for cytochrome b and subunit III of
cytochrome oxidase from Leishmania tarentolae mitochondria: RNA
editing intermediates
JOURNAL Cell 61 (5), 871-878 (1990)
MEDLINE 90263112
REFERENCE 12 (sites)
AUTHORS Bhat,G.J., Koslowsky,D.J., Feagin,J.E., Smiley,B.L. and Stuart,K.
TITLE An extensively edited mitochondrial transcript in kinetoplastids
encodes a protein homologous to ATPase subunit 6
JOURNAL Cell 61 (5), 885-894 (1990)
MEDLINE 90263114
REFERENCE 13 (sites)
AUTHORS Blum,B. and Simpson,L.
TITLE Guide RNAs in kinetoplastid mitochondria have a nonencoded 3'
oligo(U) tail involved in recognition of the preedited region
JOURNAL Cell 62 (2), 391-397 (1990)
MEDLINE 90322434
REFERENCE 14 (sites)
AUTHORS Bhat,G.J., Myler,P.J. and Stuart,K.
TITLE The two ATPase 6 mRNAs of Leishmania tarentolae differ at their 3'
ends
JOURNAL Mol. Biochem. Parasitol. 48 (2), 139-149 (1991)
MEDLINE 92107217
REFERENCE 15 (sites)
AUTHORS Maslov,D.A., Sturm,N.R., Niner,B.M., Gruszynski,E.S., Peris,M. and
Simpson,L.
TITLE An intergenic G-rich region in Leishmania tarentolae kinetoplast
maxicircle DNA is a pan-edited cryptogene encoding ribosomal
protein S12
JOURNAL Mol. Cell. Biol. 12 (1), 56-67 (1992)
MEDLINE 92107198
REFERENCE 16 (sites)
AUTHORS Maslov,D.A. and Simpson,L.
TITLE The polarity of editing within a multiple gRNA-mediated domain is
due to formation of anchors for upstream gRNAs by downstream
editing
JOURNAL Cell 70 (3), 459-467 (1992)
MEDLINE 92354063
REFERENCE 17 (sites)
AUTHORS Sturm,N.R., Maslov,D.A., Blum,B. and Simpson,L.
TITLE Generation of unexpected editing patterns in Leishmania tarentolae
mitochondrial mRNAs: misediting produced by misguiding
JOURNAL Cell 70 (3), 469-476 (1992)
MEDLINE 92354064
REFERENCE 18 (bases 1 to 20992)
AUTHORS Simpson,L.
JOURNAL Unpublished (1991)
REFERENCE 19 (bases 1 to 20992)
AUTHORS Simpson,L.
TITLE Direct Submission
JOURNAL Submitted (03-JUN-1986) Larry Simpson, Department of Biology, UCLA,
Los Angeles, CA 90024-1662, USA
REFERENCE 20
AUTHORS Thiemann, O.H., Maslov, D.A. and Simpson, L.
JOURNAL EMBO J. 13 (23) 5689-5700 (1994)
TITLE Disruption of RNA editing in Leishmania tarentolae by the loss of minicircle-encoded guide RNA genes
COMMENT 11-6-99 - LS revised the LEIPKMAX sequence features for NTI.
Inserted C to correct frameshift at 10,460.
Also deleted a C at nt 14,641.
COMMENT This file is created by Vector NTI
http://www.informaxinc.com/
COMMENT ORIGDB|GenBank
COMMENT VNTDATE|174755760|
COMMENT VNTAUTHORNAME|Larry Simpson|
COMMENT VNTEXTCHREPL|Animal/Other Eukaryotic
FEATURES Location/Qualifiers
misc_RNA complement(102..150)
/citation=[17]
/vntifkey="53"
/label=gM150
/note="guide RNA (gM150) This gRNA was discovered as part of a mis-editing gRNA/mRNA chimeric molecule and the precise editing role is unknown."
misc_RNA complement(347..395)
/citation=[10]
/vntifkey="53"
/label=gND7-II
/note="guide RNA (gND7-II)"
rRNA 438..1610
/gene="12S rRNA"
/citation=[3]
/product="12S ribosomal RNA"
/vntifkey="58"
/label=12s\rRNA
rRNA 1639..2249
/gene="9S rRNA"
/citation=[2]
/product="9S ribosomal RNA"
/vntifkey="58"
/label=9s\rRNA
misc_RNA 2239..2291
/citation=[10]
/vntifkey="53"
/label=gCYb-II
/note="guide RNA (gCYb-II)"
CDS 5403..6481
/gene="CYb"
/product="cytochrome b"
/vntifkey="4"
/label=Cyb
/note="Transcript is 5' edited. with insertion of 39 U's in 15 sites."
misc_feature 5403..5425
/gene="CYb"
/citation=[8]
/vntifkey="21"
/label=Cyb-PER
/note="preedited region of Cyb"
misc_feature 6521..6606
/gene="MURF4"
/citation=[14]
/citation=[12]
/vntifkey="21"
/label=A6-PER
/note="Preedited region of A6"
misc_RNA 9893..9908
/gene="COII"
/citation=[10]
/vntifkey="53"
/label=gMURF2-I
/note="guide RNA (gMURF2-I)"
misc_RNA complement(10117..10139)
/citation=[10]
/vntifkey="53"
/label=gCO2
/note="guide RNA (gCO2); This gRNA edits in cis. It is located at the 3' end of the CO2 mRNA and folds back to mediate editing of the mRNA."
misc_feature replace(10146..11190,"")
/gene="MURF2"
/citation=[8]
/vntifkey="21"
/label=Misc_Feature(MURF2)_15
/note="Preedited (genomic) version of the MURF2. Edited string is found at bases 10169..11190 L07545."
misc_RNA complement(13091..13145)
/citation=[10]
/vntifkey="53"
/label=gMURF2-II
/note="guide RNA (gMURF2-II)"
misc_RNA complement(16724..16752)
/citation=[10]
/vntifkey="53"
/label=gND7-I
/note="guide RNA (gND7-I)"
misc_RNA complement(16754..16803)
/citation=[10]
/vntifkey="53"
/label=gCyb-I
/note="guide RNA (gCYb-I)"
divergent_region 16811..20992
/citation=[4]
/rpt_type=tandem
/vntifkey="34"
/label=Divergent\region
/note="divergent region; Approximately 9 kb maxicircle sequence has not yet been determined. Hybridization evidence indicates that this also contains similar tandem repeats"
misc_RNA complement(16976..17021)
/citation=[16]
/vntifkey="53"
/label=gRPS12-VI
/note="guide RNA (gRPS12-VI)"
CDS 2345..2621
/vntifkey="4"
/label=ND8\(G1)
/note="Transcript is pan-edited only in LEM125. 215 Y's inserted in 99 sites and 41 U's deleted in 17 sites."
CDS complement(2678..2977)
/vntifkey="4"
/label=ND9\(G2)
/note="Transcript is pan-edited only in LEM125. 335 U's inserted at 125 sites and 40 U's deleted at 15 sites"
CDS complement(2968..3268)
/vntifkey="4"
/label=MURF5
/note="NH2 terminus uncertain; Previously called ORF10;
Editing has not yet been examined for this gene; putative"
/codon_start=1
/transl_table=4
/protein_id="AAA96600.1"
/db_xref="PID:g340596"
/db_xref="GI:340596"
/translation="STYTVTNYHKKNIILFIHKILKLNTFNCTSWKIILLLNNLYCVD
NYNSIYFNLNGILLWLNLLHINIIIIKYSFLILLNNLEYLIIFFLYNLISIKYKDV"
CDS 3286..4460
/vntifkey="4"
/label=ND7
/note="Two editing domains. "
misc_feature 3315..3326
/vntifkey="21"
/label=ND7\PER-II
/note="Preedited region II in ND7 mRNA"
misc_feature 3497..3502
/vntifkey="21"
/label=ND7-PER-I
/note="ND7 preedited region I"
CDS 4512..5362
/vntifkey="4"
/label=CO3
/note="cytochrome oxidase 3. 5' edited. 29 U's inserted in 12 sites and 15 U's deleted in 5 sites."
misc_feature 4509..4553
/vntifkey="21"
/label=CO3-PER
/note="Preedited region of cytochrome oxidase 3"
CDS 6528..7123
/vntifkey="4"
/label=A6\(MURF4)
/note="A partially pan-edited gene. 146 U's inserted in 46 sites and 5 U's deleted in 4 sites."
CDS complement(7120..8456)
/vntifkey="4"
/label=MURF1
/note="Unedited gene."
/note="NH2 terminus uncertain"
/citation=[6]
/codon_start=1
/transl_table=4
/protein_id="AAA96601.1"
/db_xref="PID:g896286"
/db_xref="GI:896286"
/translation="KSLFLYLIHIILFLLLYSFIILCDYTSLFYLSFDLIWLIIINII
ILTILDSYICFIFLLLFLFCFFFLFCFLNFDTRFVFMIIIMQYIIIFMFLHVIHILFI
SILFELFSLLLFLILISSRFGYKILILWYYYMINLINFILLFVLLYYMILNYCFYLCD
FCFLIFDEEWLGILCLFYILLILFKLYIAILILFLEQLYIRLGVFIFIYMLTFYVLFC
FILIILLICFIYFYIIFIKLIIIQSITCVLIGLNSFAIVSLLFVLSVNNFSFLFLIFI
STKNYIFYMYLNFHLIYSLSLIILIILYYFFIVYNMFDIKYNENYFLINFIFFSFFNN
LLISIMIACIFLCIGSIPIVFGFFLKVFCLLLHLSYLGICIVFFSIIWLIIIYIFYFR
LIINIFIFSYQFIGFWVVRLHILGFSNLFFILSFSIFILFFDIINLFDLIL"
CDS 8420..8584
/vntifkey="4"
/label=G3
/note="G-rich region 3. 3 gRNAs identified in LEM 125 strain only. 35 U's inserted in 15 sites and 14 U's deleted in 3 sites."
CDS complement(8548..9489)
/vntifkey="4"
/label=ND1
/note="Unedited gene"
CDS 9496..10124
/vntifkey="4"
/label=CO2
/note="Cytochrome oxidase 2 - edited in one internal domain. 4 U's inserted at 3 sites."
misc_feature 10001..10004
/vntifkey="21"
/label=CO2-PER
CDS 10152..11191
/vntifkey="4"
/label=MURF2
/note="Transcript is 5' edited. 28 U's inserted in 10 sites and 4 U's deleted in 2 sites. Inserted a C at nt 10,460 to correct frameshift- unresolved problem."
CDS complement(11182..12816)
/vntifkey="4"
/label=CO1
/note="Cytochrome oxidase 1 - unedited."
/translation="MFWLCLVCLSVSHKMIGLCYLLVAILSGFVGYVYSLFIRLELSLIGCGILFGDYQFYNVLITSHGLIMVFAFIMPVMMGG
LVNYFIPVMA GFPDMVFPRLNNMSFWMYLAGFGCVVNGFLTEEGMGVGWTLYPTLICIDF HSSLACDFVMFAVHLLGISSILNSINLLGTLFCCRRKFFSFLSWSLFIWA
ALITAILLIITLPVLAGGVTLILCDRNFNTSFYDVVGGGDLILFQHIFWFFGHPEVYIILLPVFGLISTIVEVIGFRCVFSTVAMIYSMILIAILGMFVWAHHMFVVGMDVD
SRAYFGGVSILIGLPTCVKLFNWIYSFLYTDMIITFEV YFVIMFIFMFLIGAVTGLFLSNVGIDIMLHDTYFVVGHFHYVLSLGAVVGFFTGFIHFLAKWLPIELYLFWMF
YFISTLFIGSNMLFFPMHSLGMYAFPRRISDYPVSFLFWSSFMLYGMLLLASLILFLCALFCVFLFWDYCLFFVSLF VFSLYCFFYFSTWLPCVMVLYLLLVDFAHIVLDY
LFLILCFCFVFFIFFW QSLFLFFYI"
CDS complement(12866..13059)
/vntifkey="4"
/label=G4
/note="G-rich region 4. Pan-edited only in LEM125 strain. 14 gRNAs identified. 326 U's inserted in 110 sites and 5 U's deleted in 2 sites."
misc_feature 12890..13043
/vntifkey="21"
/label=G4-PER
CDS 13153..14466
/vntifkey="4"
/label=ND4
/note="NADH dehydrogenase 4 - unedited"
CDS complement(14458..14644)
/vntifkey="4"
/label=ND3\(G5)
/note="NADH dehydrogenase 3. Pan-edited only in LEM125. 6 gRNAs identified. 161 U's inserted in 71 sites and 5 U's deleted in 3 sites. Sequence error. One C deleted at nt 14,641."
CDS 14675..14850
/vntifkey="4"
/label=RPS12\(G6)
/note="Ribosomal protein S12 - pan-edited in 3 domains. 117 U's inserted in 49 sites and 32 U's deleted in 13 sites. "
misc_feature 14673..14850
/vntifkey="21"
/label=RPS12-PER
/note="Three domains of editing"
CDS 14924..16696
/vntifkey="4"
/label=ND5
/note="NADH dehydrogenase 5 - unedited"
misc_feature 10146..10169
/vntifkey="21"
/label=MURF2-PER
BASE COUNT 8051 a 1990 c 2437 g 8514 t
ORIGIN
1 gaattcaaaa caaataaaac ccaaaacaaa taaaatccaa attaaattaa attaaattaa
61 attaaattaa attaaaaaca aatttcgttg acacaacttt taacaatttg tttcatatat
121 aatctaaatt tttgttgttg cttgttttat accgaaaagt ttgtaatatt atttttactt
181 ttaagtaaaa gtttaattta tgttttaatt ttatttataa actacaatca ataaaatata
241 gaaaagctta tttatgatat aatacaatac cacatgatta taaaaatatt aattataata
301 atatttacac tatttattaa aagttagtaa aaaggaaata gaaataaata atcatactcc
361 atatttatta attatttttc tacacttgta aaaatataga atatatttat ttttatagtg
421 taattatagt attaaaatat taatcaaatt taattaataa gtaatattga ttttatttaa
481 ttttaagtgt ttaattatat ttttgaatta aaattttatt atttggtatt taatatttaa
541 aaatattata tattttagtt ttaaatttgt tgttttatat ttagtttaat atttatatat
601 tagtaaataa tatagattta atttaaaatt tttatgaact gttatttata gtttaatatt
661 tttagtttaa tgtttaaata tttaactaat gaaggcacag ttgttctata tgtacctata
721 aaaaatagta aaattatttt aattaaatta ataaataatt attaacttaa cttaaaatta
781 atattatgga aaatttaaaa attaaattat ttttctaata caattcatat aatatatata
841 tatattaaat tgaatattaa aaatacaaat ttaatttgtt attaatacta ttcttttaaa
901 aatgcataga gatataatat cacatataat ttattatttt aatatttaat atttgtttat
961 acaaaagtaa ctttattgaa taaaaagaat tatttttatt aattattttt taaaaatata
1021 aaaatattgt taataaaatt atcaagtttt aaaagcgttt attaaatgcg tcggtctaag
1081 atttatattt aagattattc ttgtatatag atttttattt taataattct acataattaa
1141 aaaagtacct caatatatgt ttattagtag catagtaatt tattaactaa ttattaaagt
1201 gttccataga aaattttaaa attataacaa tctaaataaa taataaatta aaataaagat
1261 tttaaaaaaa attaaaaaat taaaataggg caagtcctac tctcctttac aaagagaaca
1321 ttttatatgt aattgtatgt ttgattgggg caatactata tctagttata tagaaaaaga
1381 actataatca ttgaaataat aaaaggttcg agcaggttaa caagcattaa tactaaatgt
1441 gtttcatcgt ctacttattg ctaataaaat tgattgttca tcaaaaatgc aattcgttag
1501 ttgggttaaa atcgttgtaa agcagatttg tttatatatt taatttatat atatatttaa
1561 aaattaatat tagtacgcaa ggatctatta tttgtaattg aaattaaaaa agcatgcgtt
1621 tataataata attatacgta gtcaattgtt attattcata ttaatttttt taaaagtttt
1681 ttaattttat attagtttat ttgtttacaa atttaaatta tatttcatta tttaggaata
1741 gttaataata atttataatt ctgattagat ttatttgtta atgctattaa aggggtgtgg
1801 aaaaagtgtt aaattattta tatatttaaa taataaataa aatataactt attagtcaga
1861 aatggatgcc agccgttgcg gtaatttcta tgcttttaaa tattatacat ttattttatt
1921 aatttgttac tatttaattt tagtcaataa aaaatattaa tatttttatt tgtttttaaa
1981 caccgtccgg tatatgcaaa taaaaaatga cattaattat taattatatt atattatatt
2041 tattcacata agtcaacaat atctatttac tgtttttgac aacatgataa ggattataaa
2101 tggaattata aattttataa tcaaaactaa tttattatat taaattagca tgtttagata
2161 aaacaataaa tttagaaggt attgttgccc accattcttt gtaataaaga caacgtgcag
2221 taattaatat atttataaaa atatattttc tcatgttaaa cctttgttac tttttttatt
2281 atttagaaaa gatgtaagtg ccaatataaa taaacatata taatgtatta aattaaatta
2341 aatagtaagg agagttttcg gaaggaggga tcggaccagg aggaccagag aggtttcggg
2401 aaccagcgat ttgatttggg agaacggagc cgccgagtga aattttgccc aagagccttt
2461 tttagagcgg gagaagagtt ggatcggccg aggaaaagat cgttttcgga agggtttgag
2521 caggccaaca ttttgacttt tttgccaact tgcacaggag ggagccagaa gtctgcacct
2581 aaagtttagt tttgggagat tttttgaagg gagaggactt tcgagaagta tatttgatta
2641 ataatttaat aaattaattt tatagacagt tctaacataa atatcttttg caaattggac
2701 accccacaaa atgtggctcc ctatcttcct ctctaaatac caaaatcccc aaaatggtct
2761 ttccccctca atcctcgaat gtctcttccc ccccaaatcc taaatccgtt caatctcgct
2821 ctctctcccc cctctcctta aaaactcgct ttccaaaaaa cttatctcga aaaaaccccg
2881 ctcttcttct ctctaaaaat ctttatctca aactcccctc aaaaaatctt ccctcaaaaa
2941 aacctctccc ctcccccccc gaaacttaaa catctttata cttaatagat attaaattat
3001 ataagaaaaa tataattaaa tactctaaat tatttaataa tattaaaaaa gaatatttta
3061 taataataat attaatatgc aataagttta atcataataa aataccattt aaattaaaat
3121 atattgaatt gtaattatca acacaataca agttatttaa taaaagtata attttccatg
3181 aagtacaatt aaaagtattt aattttaaaa ttttatgtat aaacaaaata atattctttt
3241 tatggtaatt agttacagtg taagtagatt agttttaata gtaatttaaa ttttatttag
3301 ccgactacac gataaatata aaaagacact tgtatagatt tactttcgga ccccagcatc
3361 cagcagccca tggcgtatta tgttgtttat tatatctttc tggagaattt ataacgtata
3421 tagatgtaat tattgggtat ttacatcgag gtacagaaaa gttatgtgaa tataaaacag
3481 tagagcagtg tttaccgatg aagactggat tatgtaagtg tagtttgtaa tgaacattta
3541 ttatctttat gttttgaata tatgttaaga tgctgtctag caatacgttg tgcatttatg
3601 cgtctattaa tgtgtgaatt tacgcgatgt tttaatgggc ttttatgttg ttcttgcatg
3661 gttatggata taggttcatt atcaccaatg ttgtgatcat ttgaagagcg tgacaagtta
3721 atgacttttt ttgatttatg ttgcggttgc agaatgcatt tagcgtttat gtgtttatta
3781 ggtctattag atgattttgt tttcggattt atagattttt tgttaatgtt atgtatttca
3841 tgtttatttg ttttagattt gtatgatttg ctttttgtag gtaatagact tttgtatttg
3901 cgtttacgag gccttgcatt ttttgatata tttgacttat gctttaatag tattagtggt
3961 tgtttatcta gatctttagg tatggtatga gatgtaagat tatatagttg ctatgaatta
4021 tactttatgt tggtttttga ttattgtttt tgttatttag gtgatgcatt cgaccgtctt
4081 tttttacgtt tatttgatat gcgaatgagt atccttttat gcaagcagtg tttttttgta
4141 ggtttttttg tttttggctt tgtatgttta tttgattata tgtatgtgga tgttactata
4201 gaaaccataa ttagtttatt ttatagttta tgatgttgta ttttaccagg ctgttctttt
4261 gcaaatgttg aacatccaaa aggtgaatat agcctatttt tatgcttttt atatggattt
4321 atctcacgtt tacgtattcg ttgtgcagat tttgtacata tttgtttatt agatgtaatg
4381 atgcgtggtt tcatgttaca tgacttagta gcagttatcg gaaatgttga tgttgttttt
4441 ggttctgttg acaggtaaat atatatatta gtattttaat ataaaaatat aaaaagtcat
4501 tatataaaaa aggcggaggg gttttgattt ttgtttgttt tgttggtttg tcttacctgc
4561 tatttgcata gtatatttaa ctttttgttt atgtggattg ttttgtatta tgtttggtag
4621 ttttattttt atagattatt gttttatttg tttttttgca tgtttattat tttgtttggt
4681 atgtttatta tgtgacttat ttgtagactc tttaagaggt ttatttgatg tatgttgctt
4741 tatacgttgt attcagtatt gttttgtatg atttataatt agtgaattat tacttttttt
4801 atctttattt tatgtagtat ttagtttagt tttatttgtt agtgttgaat ttgcatttgt
4861 ttttgttata ccagtaatgt ttagttgttt aatttgtgat tttggttttg tattttattg
4921 atattttatt gatattttta atttactaat taatacattt ttgttatttg tgagtggttt
4981 attcgtaaat tttgttttgt ttttattttg atttcgtttt tttttatgtg ttttatttat
5041 gttatgagta ggaatattat ttggtttttt atttttgtga aatcaagtat gagaatttgc
5101 attattattt gtaacatgta gctgtggagt gtttgggtca atattatttt taatagattt
5161 attacatttt agtcatgtgt ttttaggtat atttttatta tttttatgtt ttagtcgttg
5221 ctttaatttt ttgtgtatgg atactcgttt tgttttttta tatgtagtct gtttatattg
5281 acattttgta gattgtgttt gatttttttt attacgattt gtatattttg atgtgttaag
5341 tgtagtatac ttatatgcat aagaaaataa ataaatttaa tttaaatttt aaataattat
5401 aaaagcggag agaaaagaaa aggctttaac ttcaggttgt ttattacgag tatatggtgt
5461 aggttttagt ttaggttttt ttatttgtat gcaaattata tgtggtgttt gcttagcatg
5521 attatttttt agttgcttta tttgtacaaa ttgatatttt gtattatttt tatgagattt
5581 tgatttagga tttgtgatac gtagtacaca tatatgtttt acatctttat tattttttct
5641 tctttatgtg cacattttta aatgcatagt attgataata ttatttgata ctcatatttt
5701 agtatgagct gtaggattta taatatatat atttatagta gttataggtt ttattggtta
5761 tgtgttacca tgtacaatga tgtcgtattg agggttgact gtttttagta atattttagc
5821 aactgtgcca gtgatcggta cctgactttg ttattgaatt tgaggaagtg aatatattaa
5881 tgacttcact ttacttaaat tacacgtttt acacgtttta ttaccttttg tattaatatt
5941 agtaatattt atgcatttat tttgtttaca ttactttatg agttctgatg gtttttgtga
6001 tagatttgca ttttattgtg aacgtttatg cttttgcatg tgattttatt taagagatat
6061 gtttttagct tttttaatat tattttatgt agtatacttt atattcataa attgatattt
6121 tgtttttcat gaagagtcgt gagtaattgt tgacacattg aaaacatctg ataaaatttt
6181 accagagtga ttttttctat ttttatttgg ctttttaaaa gcagtccctg ataaatttac
6241 tggtttacta ttaatggtaa tactattatt ttcattattt ttatttatat taaattgtat
6301 attatgattt gtttattgta gaagttcatt attgtgattt acatattcat taatattatt
6361 ttatagtata tttatgagtg gttttttagc tttatatgta atattggcat atcccatatg
6421 aatggagtta caattttggg tattactttt atttatgcta gttgtatgta gattagatta
6481 attttgaatt atattatata aaaaattata tcagattaag ataaataagg gttggaagaa
6541 attgcgaata ggaagggatc cagaaaggaa attagtaaga ccgagaagga gagaagggag
6601 agagagattc gtgttattta atttttatgg attgattgta tattattgta ttacatattt
6661 aaatgtttat attttatttt gtatagtttt tatgtattat atggcatttt tattttgttt
6721 ttgcttttta ttagatttta tattatttgg tagcctttta gtcggagatg catttatgga
6781 tgtatttttt ttacgatatt tattatgtgt tttagaatgt ttttctttat tatgtagatg
6841 tatatctaca tttttacgaa tgttttgtaa tttattatct tcacattttt taatgttaat
6901 gttttgtgac tttgtatatt tttttataat atttttttta ttttttataa tgtgtgattt
6961 tatttatttt attatattta catttgcaat gttattttgt ataatttttt atttattttt
7021 atatgcatta gatatgtttt gtgcattatt acaaatattt atattttgta atatgataat
7081 gcagttaata atggattttt tattattatt atcttttcat taaattataa aattaagtca
7141 aataaattaa taatgtcaaa aaatagaatg aagatgctaa aacttaatat aaaaaataga
7201 tttgaaaatc ctaaaatatg aagacgcaca acccaaaatc ctatgaattg ataagaaaat
7261 ataaaaatat ttattataag tctaaaatag aaaatataaa taataataag tcaaataata
7321 gaaaaaaata ctatgcagat acctaaataa cttaaatgta gtagtaaaca aaatactttt
7381 aaaaaaaatc caaatacaat aggaatagac ccaatgcata aaaatataca tgctatcata
7441 atactaatta ataaattatt aaaaaagcta aaaaaaataa aattaattaa gaagtagttt
7501 tcattatatt ttatatcaaa catgttataa acaataaaaa aataatataa tataattaat
7561 ataataagac ttaatgaata tattaaatga aagttaagat acatataaaa tatgtagttt
7621 tttgtagaaa taaatattaa aaataaaaaa ctaaaattgt taacactaag tacaaataaa
7681 agactaacaa ttgcaaagct atttaatcca attaacacgc aagtaatact ttgtatgatt
7741 ataagtttaa taaatataat ataaaagtaa ataaaacaaa taagtagtat aataagaata
7801 aaacaaaaaa gaacataaaa agtcagcata taaataaaaa taaatacacc aagtcgtata
7861 tataattgtt ctaaaaataa aattaatata gcaatatata atttaaataa aattaataat
7921 atataaaata gacaaagaat accaagtcac tcttcatcaa atattagaaa gcaaaagtca
7981 cataaataaa aacaataatt taatatcata taatataata atacgaataa tagtataaag
8041 tttattaaat ttatcatata gtagtatcat aatattaata ttttataccc aaacctacta
8101 gaaattaaaa tgagaaaaag aagtagacta aataattcaa aaagtattga tataaatagt
8161 atatgtatta catgtaaaaa cataaatatt attatgtatt gcattattat aatcataaat
8221 acaaatctgg tatcaaaatt taaaaaacaa aacagaaaaa agaaacagaa tagaaatagc
8281 aataaaaata taaaacatat atatgagtct aaaatagtta atattattat attaataatt
8341 attaatcata ttaaatcaaa agataaataa aatagagaag tgtaatcgca taagataata
8401 aaactatata gcaataaaaa taaaattata tgaattaagt ataagaacaa ggatttttga
8461 aaggagagga cagtcttaag gatttttgag gtagagattt gaggggaaag ggggggacca
8521 gaagaacatt taaaagagtt ttcgatatta aaataacata gctattattt ttgttgtgaa
8581 aagtcaaata aacattagta cacacatata aaataaaaat attaaaataa aagcctgtgc
8641 agttgttatt tttaatctgt atccaataac tcttggataa aaaaatccaa aaattaaaat
8701 aagtatagct ttaaaacaga taaataaacc accaaaacat aggcttgcaa ataaaagtgt
8761 tgtgagtaag atgtgattga tctcaagtac agagtataaa acaaaaaaaa atcctgataa
8821 ttcagtgatt aggcctgcta ctaattcact ttcacattcc atatagtcaa acggtaattt
8881 taacccatct aataacatac ttactcaaaa tacacttata aataatacgc cagcaatata
8941 aaaatttgta atataaattt gaccaacgca aacatcttta ataccaaaga agctaaagta
9001 atctaaagaa taaatagtag tatatagtaa aaatatgccg ctttctgata taatactaaa
9061 gaacattgtt ctcatagcag ataagtaaac aaaacaacta gagaataaaa aacagcctac
9121 aaaaaatgtg ctgaacatac tacaaaaaac gtgaacacat aacataactg tcaatgtaaa
9181 tccagtgtct aataataata tgaaacctat tggaaaataa aatcacccta aaaatataca
9241 gcatgcagta ataatcatag cgcctattaa gtaaataatg tcaaagctaa tgacaaatat
9301 tataaattta ataaataatt ttattccatc agtaataggt gtaaggatac caaaaaaaca
9361 aagagcagga ccaattctta tttgaaccaa tgctaaaatt cttctttcac aaagcgttac
9421 aaagccggtt aagataagta caactaaaat atcaataata ataataataa taatgtcaat
9481 atttaacatt ttaaaatggc ttttatatta tcattttgaa tgatattttt attagattct
9541 gttattgttt tgttatcttt tgtatgtttt gtatgtgtgt gaatatgtgc attgttgttt
9601 tcaactgtat tattagtgtc aaaattaaat aatatatatt gtacttgaga cttcactgct
9661 tctaagttca ttgatgttta ctgatttact attggtggta tgttttcatt aggactttta
9721 ttacgtttat gtttactttt atattttggg catttaaatt ttgttagttt tgatttgtgt
9781 aaagtagtgg gatttcaatg atactgagtt tattttattt ttggagaaac tacaatattt
9841 agtaatttaa ttttagaaag tgattatatg ataggagact tacgtttatt acaatgtaat
9901 catgtattaa ctttattaag tttagttata tataaattat gattatcagc tgtcgatgta
9961 atacattcat ttgcaatatc aagtttagga gttaaagtag agaacctggt cgctgtaatg
10021 aaatagttct attttcatca aataatgcca cagtatatgg acaatgtagt gaactctgtg
10081 gtgtcttaca tggatttatg ccaatagtaa tttgttttat ataggtatat aatctatatt
10141 ttattattat taggggaaag aaggactgag tcgtgtattt gatttattgt gtgttagaag
10201 ttatgatttc atattatgat gatttgattt agactttatt ttatatgatt ttgtttttga
10261 ttttgtagta tgtataactt ttatatttgt atttgtatta ggtttttttc ttagaatttt
10321 ttttagtttt gtatttgttt tattatttat agtatttttt ggtttgtttt cattatcatt
10381 tttatataca ggttatttta tatattatat atatatatta tataatttta tatgttattt
10441 tttttgtttt agtattgccc tatattatat agaatttttt acatatttat tgtgttttat
10501 atttatagat tttatatcat tttctaatca tttaatttca tattttggta taattaatat
10561 gtttaatgtt atattttgtt catatttatt ttgtttgttt tattttataa tttgctttat
10621 attttgcttt atattttttg ttatccgttg tttatttgtg ataatttatg attttttatt
10681 ttttaatttt gatatatata tatctttttt aatgtgtgat ataatatata tagattatat
10741 atgcttttta ttaatatatt ttggttttat attttcgttt ataacaggtt ttttttgttt
10801 tatatttgta ttaaattatg tgtttttagt tttatttttt gtattagcat tgttttttgg
10861 ttttttattt ttatcttatg gattatttac atttttaata tattattttt tttgattata
10921 tataatatat agtcgctcat gttttatatt attacagtca gtagtaatat tttttaagtt
10981 tttatatttt gatgtatttt ttatttttgt atttttatta atattattta taatttgttt
11041 ttttggtttc tttttaaaag actttttatt tttaaatatt ttttttgata tgttttcagt
11101 attattgatt tatgatgtaa ataattatag tgcattctat aatagttata accagttttg
11161 tgtaacacaa ttattagcag tttatatata aaaaaataaa aataaagatt gtcaaaaaaa
11221 tataaaaaaa acaaagcaga agcataaaat taaaaataag tagtctaaca ctatatgtgc
11281 aaagtctaca agtaataaat ataaaaccat tacacaaggt agtcaagttg aaaaatagaa
11341 aaaacagtaa aggctaaata caaataagct aacaaaaaat aagcagtaat ctcaaaataa
11401 aaaaacacag aaaagtgcac ataaaaataa tattaagctg gcaagtaata acataccgta
11461 aagcataaat gaacttcaga ataaaaatga cacaggatag tcagatattc tacgaggaaa
11521 tgcatacata cctaaagaat gcattggaaa aaaaagcata ttacttccta taaataatgt
11581 gctaataaag tagaacattc aaaaaaggta tagttctata ggtagtcatt tagcaaggaa
11641 gtgtataaaa cctgtaaaaa atccaactac cgcacctaat gataaaacat aatgaaagtg
11701 accaactacg aagtaagtgt catgcagcat tatatctatg cctacatttg ataaaaaaag
11761 acctgtcacg gcaccaatta aaaacataaa aataaacatt ataacaaagt aaacttcaaa
11821 tgtaataatc atatcagtat ataagaaact ataaattcag ttaaatagtt taacacatgt
11881 aggcaatcca attaaaattg aaacaccacc aaagtaagct ctagagtcaa catccatacc
11941 tactacaaac atatgatgcg ctcagacaaa catacctaaa atagcaatta atatcataga
12001 gtatatcata gcaacagtac taaaaacaca acgaaacccg ataacttcta caatagtaga
12061 tattaaacca aaaacaggaa gtaatataat atatacttca ggatgaccaa aaaatcaaaa
12121 aatatgttga aatagtatta agtcaccacc acccacaaca tcataaaatg atgtattaaa
12181 atttctatca cataatatta atgtaacacc accagctaat acaggtaaag taattattaa
12241 aagtatagca gttataagag cagctcaaat aaatagagat caagataaaa agctaaagaa
12301 ttttctacgg caacagaata aagtgccgag taaatttata gaatttaaaa tactagatat
12361 acctagtaaa tgcacagcaa acataacaaa atcacaggct aaacttgaat gaaaatctat
12421 acatattaaa gttggatata atgtccatcc gacacccatg ccctcttctg ttaaaaaccc
12481 attaacgaca caaccaaatc ctgctaagta cattcaaaaa ctcatattgt taagtcgagg
12541 aaataccata tctggaaacc cagccataac aggaataaaa taatttacaa gaccacccat
12601 cataacaggc attataaaag caaaaaccat aattaatccg tgagaagtaa ttaaaacatt
12661 ataaaactga tagtctccaa ataaaatacc acatcctata agtgaaagtt ctaatctaat
12721 aaataatgaa taaacatatc caacaaatcc tgaaaggatt gcaactaaaa gataacataa
12781 accaatcatt ttatgtgaca cactaagaca aacgaggcaa agtcaaaaca tatattaaat
12841 taaataattt tgacaataaa gttaataaat tttaaaataa tccaattaat ttccgtctcg
12901 cctttctccc cccccttctg ttttctcccc tcccccctct tcttcccctt cctacatctt
12961 ctcccctcta atttcgagtc ccttctcccc ctccctccaa aatctcctgc ttttcctccc
13021 tctcctttcc cctatctccc cccttttaca attatacata tatgtgtttt aatgtatttg
13081 tactaatttt attagtctca gtcaaagtat aaaaataaga ttaaattaaa ataattaaat
13141 atttataaaa aaatgtttaa atttatatta gtaatttgta attttatatt attattttta
13201 atagttactt taatatttat taattatagt ttttgtttag ccttgcagtt taattatatt
13261 tatataaata tatacttaaa ttatatcaat ttatgattta tatattttat ggggttaatc
13321 gtattctttt tgatattttt gttatctcgt aaattagtgt catatagtaa atatttttat
13381 attttattat cttatatatt tatatttttt gatgtaacat taataatttt aatcgatgat
13441 tttatgtgtt ttatgatatt atttgagagt ttattttttc caatatgttt tgtaagttta
13501 ttttttaatt ttaataatcg ctttatattt gcaatatttt atttagttat atttagttct
13561 ttgagttcaa taatgtgtat aattatttgt attattatta tttttcattt taatatatta
13621 aatttacaga gttttataga tatttgtatt tttgatagtt tatatttagg attatatgtg
13681 tgaatattat tatttataat gttttctatt aagtatccaa tatgaccgtt tcatgtatga
13741 ttaccggaat tacatgtaga agttaatacg gagttaagta tattattagc cagtgttgtg
13801 ttaaaaatag gtttttttgg gttgtataaa tttttatttt taagttttaa tcaattatct
13861 atatgatttt taggttttat agacagtctt gtgatgttag gattaacatt tttagcaatt
13921 acactattat ttttaagtga ttataaaaaa ataattgcaa cttgatctgt tatacatacg
13981 ggtataggtt tgattttatt atggcataat gatattattt ttttaggatt acttatattt
14041 tgtaatttat cacatattat aagttcagcc tttatgttta tgatggtagg ttatatgtat
14101 gataattatg gagttagaat atttttaatg ttaatttcat tttttggtat tagcatatga
14161 agctctttat ttttaggtat ttttttattt aatatagatt tcccatttat gctattattt
14221 tatattgaca tttttttgtt atatggatta atttctttat catttatata catatgttgt
14281 ttttatataa tagtgttagc tgtattttta tcttcaatat atatgtatat gtgtttaagt
14341 ttttattctt ttatatgact agataaatat ttacgtttag atttaacaat taatgatata
14401 tatttgtatt ttataacaag cataatagta atattatttt tttatttaat ttatttatta
14461 ttttagtatt aaataagaga atacactatt tttttttccg tccagtcttt tacaaatctc
14521 ctctcccccc ctttccttcc cccctatttt taaccttaaa ggtaaaactc cttctgcgaa
14581 cttcttgcaa tctcgtgttc tgtctccccc gtctcccgct ctgccctttt tccctcctcc
14641 caaactaata cctatcgacc tatataaatt ataaatgcgt gaattttttg agtgagtttg
14701 cttttgttat tttagggtaa aagccacgaa cctagttccg gaatcgacgg aatttgcaaa
14761 gaagaaaaga ggttgtttgt ttttgggaac ttagcttgaa ggaatttttt ggggggagag
14821 ccaggagaaa gatttcacgg aattgttttc gtaagcaata agtaatcatt aaaataattt
14881 tatttagata gtatattgta atatatatat atatacaaat aaaatgttta tgtttttttt
14941 tatgtttttt tttatgtttg gctttatttg tggtatattt tttataggaa ggcatatatt
15001 aagtttttgg ttgtcagtgg ttttatgtat atttttagtg atgtcaacaa tatttagttg
15061 tttttgttta agtatttgta tatatgggta ttgcttttat gatttttgtt tactcattat
15121 gcttgatttt tgttttatat gattagtatt ttattgtaat ggtttttata tatttatttt
15181 atatttaata gatattgtat tttgctttat agttttttat gcattttatt atatgtattt
15241 tgatatgcta ttagccagat tttttcatat attttgatga ttcgtattat gtatgaactt
15301 ttttatatta tcatatgatt ttttaacagc atattgtggt tgagaattat taggtttatt
15361 ttcatttttt ttaatatcat acttttgata tagattttat gcattaaaat ttggatttaa
15421 agcatttttt ataagtaaag taggagatgt actattactc ttagtatttg caattacatt
15481 tttaatgaat ggttattgtg taataacatt ttatttttta acatttttgt gtgtagacta
15541 tatatttata gtatttattg tgtttttatt attaacttgt ggttttacta agtccaccca
15601 gtttggttta catatttgat taccagacgc tatggaagga ccaatcccag tatctgcatt
15661 aattcatgct gctactttag tagtttgtgg tataatatta attagttttg tattttgatg
15721 ctttgacttt tgattttgtt atttttatag tttaattggt tgatctagtt taatattggt
15781 aatgatgagt ctttgtgtat tttataattt tgatgtaaaa aggtatgtag cttttagtac
15841 aatttgtcaa ataagttttt caatgttttg ttgtttaagt ttagatttat atgtaggatg
15901 tttgtttttt tgttatcata tgttttataa agccacttta ttcatagtgt taggtgtatg
15961 aatacatttt ttttttggat tacaagatgt aagatgttat ttttttacat acttttgtgg
16021 atgtatttta gctagaatgc tattaatatt tgcaatatta aattcatgtt ctttgtgatt
16081 tttatgtggt ttttattgta aagatctttt attatgtctt ttaatgttaa catcattttt
16141 ttttatatta gaatttttgt gtgtatgttt attttttata ttttttactg taatatataa
16201 ttacttttta ttattttttt tatgttttgt atttaagtgt ttttgtctag tagatacact
16261 ttttttactt tttgactttg agtgttgtct tgtttattgt acgttttgtt tatatatgtg
16321 ttttgtattg ctattttttg tattagactt tttatatgta tttatttttt caagttactg
16381 tttattttga tctttttatt tatattatgc atcatttttt gatatagcat tatttacagt
16441 ttttataatt gatattatta agttttatat attatcgggt gttatatttt atttttttaa
16501 tatagattgt attatgtttt tttgaagggt atttttattc attacaatgg gatttttatt
16561 ttttatattt acaacatgat actttatatg cttttatatg tatatatgta tgtttatatg
16621 aaatttagtt atatatttta gatataactt aaagtattgt ttattttttt gtatgttatt
16681 tataatatac atataagaaa aaaagagtat tataatataa tatattttat atccagtcta
16741 tcagaatatt ttataagtta ttatttaaaa atttatatta tcttttaact tcaagtcata
16801 tgtgatatta ttattattat attaaaattt aaataaagta atttacaata atttatatta
16861 atttaaaatt aaattaaatt taaaaacaaa aaatgatata aaaaatagaa taagtattat
16921 aaataataat aataataata ataataataa taataataat aatacataaa gacaaattta
16981 attttatatt caagtccaca attacctaat tccataataa tatataaaat atattgtata
17041 tgtagattat aaaagtattt tatgtattat taagttaata aatattaaaa attaaaaatt
17101 aaaaattaaa aatttattaa taatacaaaa aatttgatat gaaatccctt gtgtgttcgt
17161 cgaatataaa aattatgaac gaatttttgt atggtcagca aaataatata agttcattaa
17221 aagtatgaac gaaattctta tgaatgtaaa attataaaaa tcctatatca aatataaaaa
17281 ttatgaacga atttctgtat gtgggcaagc aaaaattatg aacggatttc tgtatgaaca
17341 acaaaaatta tgaaaacttt atatcaaaaa taaaaattat gaacgaattt ttgtatggcc
17401 agtaaaaatt atgagaatcc tatattaaat ataaaaatta tgaacgaatt tctgtattgg
17461 cagtaaagat tatgaacggg tttctgtatg aacagcaaaa attatgaacg aatttctgtg
17521 gtgtgtatat taaacatgaa cgattcctgt acggatagta aaaattttag gaacgcattt
17581 ctgtatggac cgtaaaaatt ctgggctgaa tataaaactt atgaacgggt tgtctgtatg
17641 aacgaccaaa aaatgaacgg gtgtctgtat acattaaata aaattaaaat aaatagcata
17701 ctgttaaaac agatagaatt gaaattaaat attgacttat ttaccttttt aaaattttat
17761 ttaaaaaatt attaatcaat ttgaatcaag ttaaatttcc gtaaattttg acagaaagtt
17821 ccataaaatt aaattaaatt aaattaaatt aaattaaatt atataaatca gaacaaattg
17881 agataaaatt tgaatttaaa aaatttaaca caaaatttgc aaagacccta taataatata
17941 ataatataat aatataataa tataataata taataatata ataatataat aataatataa
18001 tataatataa tataataata taataataca aataatataa taatataata gtataataat
18061 ataataatat aataatataa taatataata atataataat ataataatat aataatataa
18121 taatataata atataaataa tataataata taataatata ataatataat aatataataa
18181 tataataata taatattatc aagcttgtta taaaaaactt tgttttttat aacaagcttg
18241 atactctcgg tatggtttta aaaataaatc aaatttgata tggtttcggc ttggaattga
18301 ctgctcgcct tttaattttc cattaaaatc ccaccgattt atgattagac aacttaaaag
18361 ataattaaat taagttattt tcatattaaa acaagttatt cccatattaa aacaagttat
18421 tcccatatta aaacaagtta ttcccatatt aaaacaagtt attcccatat taaaacaagt
18481 tattcccata ttaaaataaa tctttaaatg accacaaatt ttgacagagt tctataaaat
18541 tagacaaacg tacttaaaac tgtcgacaaa tcatataatt actatatgaa atcgtagtta
18601 attaataaag cacaaaaaca aaataaatcc aaaataaaat caaataaaat cgaaatcaaa
18661 taaaattaaa tttaaaacaa ataaaaccga aattaaatta aattaaatta aattaaatta
18721 aattaaatta aattaaatta aattcaaaac aaataaaatc caaaacaaat taaaataatt
18781 ttacaaaatt gacaaacttg tacttagaaa cattgacaaa ttatatagtt actatatgaa
18841 atcgtagtta attaataaat tacaaaaaca aaataaatcc aaaattaaat taaattaaat
18901 taaattaaat taaaataaat taaattaaaa ttaaattcaa aacaaataaa atccaaaaca
18961 aataaaatac aaattaaatt aaattaaatt aaattaaatt aaattaaatt caaaacaaat
19021 aaaattcaaa acgaataaaa gccaaaacaa attaaaataa attttgacag acagtttcac
19081 aaaattgaca aacttgtact tagaaatatt gacaaattat ataattacta tatgaaatcg
19141 cagttaatta ataaattaca aaaacaaaat aaatccaaaa ttaaattaaa ttaaattaaa
19201 ttaaattaaa ttaaattaaa ttaaattaaa ttaaattaaa ttaaattaaa tcaaaattaa
19261 attcaaaaca aataaaatcc aaaacaaata caaattaaat taaattaaat taaattaaat
19321 caaaattaaa ttcaaaacaa ataaaatcca aaacgagtaa aagccaaaac aaattaaaat
19381 aaattttgac agacattcca caaaattgac aaacttgtac ttagaaatat tgacaaatca
19441 tataattact atatgaaatc gcagttaatt aataaattac aaaaacaaat aaatccaaaa
19501 taaaatcaaa taaaatcgaa attaaaaaaa attaagttta aaacaaataa aaccgaaatt
19561 aaattaaatt aaattaaatt aaattaaatt aaattaaatt aaattaaatt aaattaaatt
19621 aaattaaatt aaattaaatt aaattaaatt caaaacaaat aaaatcgaaa ttaaaaataa
19681 aaaaattaaa ataaaaacta aaatcaaatc aaaattaaaa aataaattga aataaaattt
19741 gaataaaaaa attaacaaaa atctgcaaag acccctataa tatataatat ataatatata
19801 atataataaa taatataata atataataat atatataata atataataat aatataataa
19861 tataataata taatataata taataatata ataatataaa taatataata atataataat
19921 ataataatat aataatataa taatataata atataataat ataataatat aataatataa
19981 taatataata atataataat ataataatat aataatataa taatataaca atataataat
20041 ataataatat aataatataa ataatataat attatcaagc ttgttataaa aaactatgtt
20101 ttttataaca agattgatac tctcggtatg gttttaaaaa taaatcaaat ttgatatggt
20161 ttcggcttgg aattgactgc tcgcctttta attttccatt aaaatcccac cgatttatga
20221 ttagacaact taaaagataa ttaaattaag ttattttcat attaaaacaa gttattccca
20281 tattaaaaca agttattccc atattaaaac aagttattcc catattaaaa caagttattc
20341 ccatattaaa acaagttatt cccatattaa aataaatctt taaatgacca caaattttga
20401 cagagttcta taaaattaga caaacgtact taaaactgtc gacaaatcat ataattacta
20461 tatgaaatcg tagttaatta ataaattaca aaaacaaaat aaatccaaaa ttaaattaaa
20521 ttaaattaaa ttaaattaaa ttcaaaacaa ataaaatcca aaacaaataa aatacaaatt
20581 aaatttaaaa caaataaaac cgaaattaaa ttaaattaaa ttaaattaaa ttaaattaaa
20641 ttaaattaaa ttaaattaaa ttaaattaaa ttaaattcaa aacaaataaa agccaaaaca
20701 aattaaaatc attttccgta aattttgaca gaaattttac aaaattgaca aacttgtact
20761 tagaaatatt gacaaattat atagttacta tatgaaatcg tagttaatta ataaattaca
20821 aaaacaaaat aaatccaaaa ttaaattaaa ttaaattaaa ttaaattaaa ttaaattaaa
20881 ttaaattaaa ttaaattaaa ttaaattcaa aacaaataaa atcgaaaaca aataaaaccc
20941 aaaacaaatt aaaataaatt ttgacagaca gtcccacaaa attgacaagc tt
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