Pan-editing of ribosomal protein S12 mRNA: 3 editing domains and 8 overlapping gRNAs.

                                          3’-A-UUagUaC--GUaaG----UagaaGAU---AUaaaaaCAAACCAAAAUAUAG-5’
                                                  | :||:|||  ::|||    :|:||:||   |||||||||||||||||||||:
              3’-UAUagaUaagaUAUGCACaUaaU-GGAGACaUAC-CAAAUAC--ACAUCUC-5’              3’-UaaaUUaaaAUaUaagUUCaGGUGUUa
                 ||||:||||:|||:||||||||| |::|:|||||| |||||||  |||                       :|||::|||||||||:||||||||:||
 5’-CAGACAAUAAAUUAUAuuuAuuuuAUGCGUGuAuuA*UUUUUGuAuG*GuuuAuG**UGuuC****GuuuuUUA***UAuuuuuGuuuGGuuuUAuAuuuAAGuCCACGAu
                            M  R  V  L   F  L  Y  G   L  C    V  R      F  L     Y  F  C  L  V  L  Y  L  S  P  R  L   



              3’-UUaUUAGUUGCaaCagaUaU---ACGUGaUaCgaUAUACAAAAUUUAAGAUAC-5’  3’-UGUaaaGGCC-GAU----GUaaaUaaagagCUUaGU
                 ::|||||:|||||||:||||   |||||||||:|||||||||||||||:||||        |||||||||| :|:    ::|||:|||:|:||||||
      aUGGAUUAAGGUAUUAUUA-5’                     3’-aUaUaaaUUgUgagaUaCUaaagagaUaCaAAAAAC-AAC----ACAAAAUA-5’
      ||||||:||||:                                  |||:|||||:|:|:||||||||:|:|:||||||||| |||    ||||| ||
      uACCUAGUUCCGGuAAUCGACGuuGuuuAuA***UGCAAuAuGuuAuAuGuuuAAuAuuuuAuGAuuuuuuuGuGuuuuUUG*UUG****UGuuuGuuuuuuGAAuCA
        P  S  S  G  N  R  R  C  L  Y     A  I  C  Y  M  F  N  I  L  W  F  F  C  V  F  C   C      V  C  F  L  N  H 


    
      agaCG-ACAAAUGUCACCUA----ACAAA-5’                   3’-UUCaCaaGAAGUUCagaaggagaCUU-AC----GCAUUCGCU-5’
      |:||| ||||||:||| ||     |||                           |||| ||:|||| ||:||::|:||||-||    |||||||||
         3’-ACagaUgUUggCUC----UCaCUaUCaagaUaaUUagaCGGUCCUCAACUA-5’
            |||:||:||::|||    ||||:|:|||:||||:|||||||||||||
      uuuGC*UGuuuAuAGuuGAA****GGuGGuGGuuuuAuuGAuuuGCCAGGAGUAAAGuAuuUUUCACGuuuuuuuuuGAA*UG****CGUAAGCAAUAAGUAAUCA
       L  L   F  I  V  E      G  G  G  F  I  D  L  P  G  V  K  Y  F  S  R  F  F  L  N   A      Ter

      
      UUAAAAUAAUUUUAUUUAGAU[An]-3’